Table 1 Functional enrichment of differentially expressed genes between metastatic samples, non-metastatic samples and non-malignant samples ( P < 0.05)
Category | Term | Count | P-value | Genes |
|---|---|---|---|---|
GO:0002822 | Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 4 | 0.01166 | C3, TBX21, RARA, FOXP3 |
GO:0002819 | Regulation of adaptive immune response | 4 | 0.01225 | C3, TBX21, RARA, FOXP3 |
GO:0016071 | mRNA metabolic process | 9 | 0.01427 | HNRNPL, NCBP2, UPF3A, C17ORF71, RNMT, GTF2F1, SYNCRIP, SNRPC, SF3A1 |
GO:0044092 | Negative regulation of molecular function | 8 | 0.02485 | MDFI, KDM1A, ADCY2, RGS3, WWP2, BUB1B, FOXP3, ANGPTL4 |
GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 3 | 0.02712 | NCBP2, UPF3A, C17ORF71 |
GO:0007626 | Locomotory behavior | 7 | 0.03055 | HRAS, CCR3, SEMA3F, MYO15A, CHRNA4, SEMA3A, ESPN |
GO:0051129 | Negative regulation of cellular component organization | 5 | 0.03381 | SEMA3F, RDX, CLASP2, SEMA3A, FOXP3 |
GO:0048841 | Regulation of axon extension involved in axon guidance | 2 | 0.03386 | SEMA3F, SEMA3A |
GO:0048843 | Negative regulation of axon extension involved in axon guidance | 2 | 0.03386 | SEMA3F, SEMA3A |
GO:0006370 | mRNA capping | 2 | 0.03386 | NCBP2, RNMT |
GO:0000956 | Nuclear-transcribed mRNA catabolic process | 3 | 0.03609 | NCBP2, UPF3A, C17ORF71 |
GO:0045621 | Positive regulation of lymphocyte differentiation | 3 | 0.03609 | RARA, INPP5D, AP3B1 |
GO:0051249 | Regulation of lymphocyte activation | 5 | 0.03845 | TBX21, RARA, INPP5D, FOXP3, AP3B1 |
GO:0009452 | RNA capping | 2 | 0.04215 | NCBP2, RNMT |
GO:0050919 | Negative chemotaxis | 2 | 0.04215 | SEMA3F, SEMA3A |