Skip to main content

Table 2 ORs with CIs and heterogeneity results for the various allele/genotype contrasts

From: Is rs759853 polymorphism in promoter of aldose reductase gene a risk factor for diabetic nephropathy? A meta-analysis

  Populations Studies ( n ) Allele/genotypes (n) I 2 (%) P 1 OR (95% CI) P 2
Allele contrast Susceptibility 12 9,476 52 0.02 Random: 1.37 (1.18, 1.59) <0.0001
  Type 1 4 2,350 35 0.20 Fixed: 1.75 (1.48, 2.07) <0.00001
  Type 2 8 7,126 16 0.31 Fixed: 1.25 (1.11, 1.41) 0.0003
  Caucasians 5 2,606 49 0.10 Fixed: 1.26 (1.05, 1.50) 0.01
  Asians 3 4,520 0 0.80 Fixed: 1.24 (1.06, 1.45) 0.008
  Progression 3 1,058 0 0.90 Fixed: 0.86 (0.67, 1.10) 0.24
  Type 2 2 598 0 0.76 Fixed: 0.83 (0.59, 1.16) 0.27
Additive model Susceptibility 12 3,009 51 0.02 Random: 1.78 (1.25, 2.53) 0.001
  Type 1 4 652 68 0.02 Random: 2.27 (1.19, 4.33) 0.01
  Type 2 8 2,357 38 0.12 Fixed: 1.44 (1.07, 1.95) 0.02
  Caucasians 5 797 43 0.13 Fixed: 1.40 (0.92, 2.13) 0.12
  Asians 3 1,560 55 0.11 Random: 1.60 (0.80, 3.20) 0.19
  Progression 3 263 0 0.85 Fixed: 0.63 (0.37, 1.06) 0.08
  Type 2 2 145 0 0.81 Fixed: 0.54 (0.26, 1.15) 0.11
Recessive model Susceptibility 12 4,735 39 0.08 Fixed: 1.33 (1.08, 1.63) 0.008
  Type 1 4 1,172 56 0.08 Random: 1.47 (1.08, 2.02) 0.02
  Type 2 8 3,563 34 0.16 Fixed: 1.22 (0.92, 1.61) 0.17
  Caucasians 5 1,303 27 0.24 Fixed: 1.12 (0.76, 1.64) 0.58
  Asians 3 2,260 60 0.08 Random: 1.47 (0.71, 3.05) 0.30
  Progression 3 529 0 1.00 Fixed: 0.53 (0.33, 0.85) 0.009
  Type 2 2 299 0 0.99 Fixed: 0.52 (0.26, 1.04) 0.07
Dominant model Susceptibility 12 4,735 50 0.03 Random: 1.52 (1.26, 1.84) <0.0001
  Type 1 4 1,172 63 0.04 Random: 1.93 (1.28, 2.91) 0.002
  Type 2 8 3,563 27 0.22 Fixed: 1.34 (1.15, 1.55) 0.0001
  Caucasians 5 1,303 55 0.06 Fixed: 1.45 (0.99, 2.12) 0.06
  Asians 3 2,260 0 0.95 Fixed: 1.28 (1.06, 1.55) 0.01
  Progression 3 529 0 0.75 Fixed: 1.08 (0.75, 1.55) 0.69
  Type 2 2 299 0 0.92 Fixed: 0.96 (0.55, 1.55) 0.85
Codominance model Susceptibility 12 4,735 10 0.34 Fixed: 1.30 (1.15, 1.47) <0.0001
  Type 1 4 1,172 0 0.61 Fixed: 1.38 (1.10, 1.74) 0.005
  Type 2 8 3,563 30 0.19 Fixed: 1.26 (1.09, 1.47) 0.002
  Caucasians 5 1,303 45 0.12 Fixed: 1.36 (1.08, 1.72) 0.01
  Asians 3 2,260 1 0.36 Fixed: 1.20 (0.98, 1.46) 0.07
  Progression 3 529 0 0.38 Fixed: 1.10 (0.85, 1.44) 0.46
  Type 2 2 299 44 0.19 Fixed: 1.04 (0.72, 1.50) 0.83
  1. Abbreviations: AR aldose reductase, CI confidence interval, DN diabetic nephropathy, OR odds ratio, P1P value for heterogeneity, P2P value for significance with fixed or random effects model.