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Table 2 ORs with CIs and heterogeneity results for the various allele/genotype contrasts

From: Is rs759853 polymorphism in promoter of aldose reductase gene a risk factor for diabetic nephropathy? A meta-analysis

 

Populations

Studies ( n )

Allele/genotypes (n)

I 2 (%)

P 1

OR (95% CI)

P 2

Allele contrast

Susceptibility

12

9,476

52

0.02

Random: 1.37 (1.18, 1.59)

<0.0001

 

Type 1

4

2,350

35

0.20

Fixed: 1.75 (1.48, 2.07)

<0.00001

 

Type 2

8

7,126

16

0.31

Fixed: 1.25 (1.11, 1.41)

0.0003

 

Caucasians

5

2,606

49

0.10

Fixed: 1.26 (1.05, 1.50)

0.01

 

Asians

3

4,520

0

0.80

Fixed: 1.24 (1.06, 1.45)

0.008

 

Progression

3

1,058

0

0.90

Fixed: 0.86 (0.67, 1.10)

0.24

 

Type 2

2

598

0

0.76

Fixed: 0.83 (0.59, 1.16)

0.27

Additive model

Susceptibility

12

3,009

51

0.02

Random: 1.78 (1.25, 2.53)

0.001

 

Type 1

4

652

68

0.02

Random: 2.27 (1.19, 4.33)

0.01

 

Type 2

8

2,357

38

0.12

Fixed: 1.44 (1.07, 1.95)

0.02

 

Caucasians

5

797

43

0.13

Fixed: 1.40 (0.92, 2.13)

0.12

 

Asians

3

1,560

55

0.11

Random: 1.60 (0.80, 3.20)

0.19

 

Progression

3

263

0

0.85

Fixed: 0.63 (0.37, 1.06)

0.08

 

Type 2

2

145

0

0.81

Fixed: 0.54 (0.26, 1.15)

0.11

Recessive model

Susceptibility

12

4,735

39

0.08

Fixed: 1.33 (1.08, 1.63)

0.008

 

Type 1

4

1,172

56

0.08

Random: 1.47 (1.08, 2.02)

0.02

 

Type 2

8

3,563

34

0.16

Fixed: 1.22 (0.92, 1.61)

0.17

 

Caucasians

5

1,303

27

0.24

Fixed: 1.12 (0.76, 1.64)

0.58

 

Asians

3

2,260

60

0.08

Random: 1.47 (0.71, 3.05)

0.30

 

Progression

3

529

0

1.00

Fixed: 0.53 (0.33, 0.85)

0.009

 

Type 2

2

299

0

0.99

Fixed: 0.52 (0.26, 1.04)

0.07

Dominant model

Susceptibility

12

4,735

50

0.03

Random: 1.52 (1.26, 1.84)

<0.0001

 

Type 1

4

1,172

63

0.04

Random: 1.93 (1.28, 2.91)

0.002

 

Type 2

8

3,563

27

0.22

Fixed: 1.34 (1.15, 1.55)

0.0001

 

Caucasians

5

1,303

55

0.06

Fixed: 1.45 (0.99, 2.12)

0.06

 

Asians

3

2,260

0

0.95

Fixed: 1.28 (1.06, 1.55)

0.01

 

Progression

3

529

0

0.75

Fixed: 1.08 (0.75, 1.55)

0.69

 

Type 2

2

299

0

0.92

Fixed: 0.96 (0.55, 1.55)

0.85

Codominance model

Susceptibility

12

4,735

10

0.34

Fixed: 1.30 (1.15, 1.47)

<0.0001

 

Type 1

4

1,172

0

0.61

Fixed: 1.38 (1.10, 1.74)

0.005

 

Type 2

8

3,563

30

0.19

Fixed: 1.26 (1.09, 1.47)

0.002

 

Caucasians

5

1,303

45

0.12

Fixed: 1.36 (1.08, 1.72)

0.01

 

Asians

3

2,260

1

0.36

Fixed: 1.20 (0.98, 1.46)

0.07

 

Progression

3

529

0

0.38

Fixed: 1.10 (0.85, 1.44)

0.46

 

Type 2

2

299

44

0.19

Fixed: 1.04 (0.72, 1.50)

0.83

  1. Abbreviations: AR aldose reductase, CI confidence interval, DN diabetic nephropathy, OR odds ratio, P1P value for heterogeneity, P2P value for significance with fixed or random effects model.
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European Journal of Medical Research

ISSN: 2047-783X

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