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Table 2 Main results in the total and subgroup analysis

From: Association of CYP1A1 MspI polymorphism in the esophageal cancer risk: a meta-analysis in the Chinese population

Analysis model Study groups n Random-effect model Fixed-effect model Heterogeneity
OR (95% CI) OR (95% CI) χ 2 P
C vs. T Total analysis 12 1.25 (1.04 to 1.51) 1.23 (1.11 to 1.37) 33.46 0.000
  PB 6 1.22 (1.05 to 1.42) 1.22 (1.05 to 1.42) 1.49 0.914
  HB 6 1.30 (0.90 to 1.90) 1.25 (1.08 to 1.44) 31.93 0.000
  ESCC 9 1.18 (1.00 to 1.39) 1.17 (1.04 to 1.32) 14.48 0.070
  South China 3 0.93 (0.76 to 1.14) 0.93 (0.76 to 1.14) 0.71 0.702
  North China 9 1.38 (1.12 to 1.70) 1.37 (1.21 to 1.55) 22.21 0.005
CC vs. TT Total analysis 12 1.42 (0.99 to 2.04) 1.42 (1.15 to 1.75) 29.24 0.002
  PB 6 1.38 (1.02 to 1.88) 1.38 (1.02 to 1.88) 0.45 0.994
  HB 6 1.46 (0.70 to 3.04) 1.45 (1.09 to 1.93) 28.75 0.000
  ESCC 9 1.29 (0.94 to 1.77) 1.27 (1.00 to 1.62) 12.34 0.137
  South China 3 0.82 (0.54 to 1.25) 0.82 (0.54 to 1.24) 1.26 0.531
  North China 9 1.72 (1.16 to 2.56) 1.73 (1.35 to 2.22) 18.97 0.015
CC vs. CT Total analysis 12 1.09 (0.89 to 1.33) 1.09 (0.89 to 1.32) 10.90 0.452
  PB 6 1.07 (0.80 to 1.43) 1.06 (0.80 to 1.42) 2.93 0.711
  HB 6 1.12 (0.78 to 1.59) 1.11 (0.85 to 1.45) 7.94 0.160
  ESCC 9 1.01 (0.80 to 1.28) 1.01 (0.80 to 1.28) 7.91 0.442
  South China 3 0.80 (0.53 to 1.21) 0.80 (0.53 to 1.21) 1.53 0.464
  North China 9 1.19 (0.95 to 1.50) 1.19 (0.95 to 1.50) 6.63 0.577
CC + CT vs. TT Total analysis 12 1.35 (1.06 to 1.72) 1.37 (1.17 to 1.59) 26.54 0.005
  PB 6 1.36 (1.10 to 1.69) 1.36 (1.10 to 1.69) 4.10 0.536
  HB 6 1.39 (0.86 to 2.23) 1.37 (1.11 to 1.70) 22.44 0.000
  ESCC 9 1.28 (1.04 to 1.59) 1.28 (1.08 to 1.52) 11.73 0.164
  South China 3 0.97 (0.73 to 1.28) 0.97 (0.73 to 1.28) 0.11 0.947
  North China 9 1.52 (1.14 to 2.02) 1.58 (1.32 to 1.89) 18.30 0.019
CC vs. TT + CT Total analysis 13 1.35 (1.03 to 1.76) 1.34 (1.13 to 1.59) 26.94 0.008
  PB 7 1.41 (1.06 to 1.89) 1.43 (1.13 to 1.81) 8.26 0.219
  HB 6 1.30 (0.79 to 2.14) 1.25 (0.98 to 1.60) 18.16 0.003
  ESCC 9 1.14 (0.88 to 1.47) 1.12 (0.90 to 1.40) 10.22 0.250
  South China 3 0.82 (0.56 to 1.20) 0.81 (0.56 to 1.19) 1.63 0.443
  North China 10 1.55 (1.17 to 2.06) 1.53 (1.26 to 1.86) 17.20 0.046
  1. PB population-based, HB hospital-based, ESCC esophageal squamous cell carcinoma, South China including Taiwan, Jiangsu, and Guangxi; North China including Shaxi, Xinjiang, Gansu, Ningxia, Shandong, and Henan.