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Table 1 Relationship between miR-133a and clinicopathological parameters in NSCLC \( \left(\overline{\mathbf{x}}\pm \mathbf{s}\right) \)

From: MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance

Clinicopathological feature n miRNA-133a relevant expression (2 Δcq )
Mean ± SD t P value
Tissuea NSCLC 125 2.0108 ± 1.3334 6.949 <0.001
  Adjacent non-cancerous lung 125 3.6430 ± 2.2625   
Age (years) <60 57 1.8321 ± 1.2583 1.377 0.171
  ≥60 68 2.1606 ± 1.3846   
Gender Male 75 1.9552 ± 1.2893 0.569 0.570
  Female 50 2.0942 ± 1.4060   
Smoke No 38 1.7792 ± 1.2891 1.565 0.122
  Yes 30 2.3217 ± 1.5689   
Tumor size (cm) ≤3 (pT1) 60 2.3058 ± 1.2512 −2.423 0.017
  >3 (pT2, pT3, pT4) 65 1.7385 ± 1.3581   
Lymph node metastasis No 56 2.2662 ± 1.3316 −1.951 0.053
  Yes 69 1.8035 ± 1.3079   
Vascular invasion No 90 2.0787 ± 1.3777 −0.912 0.364
  Yes 35 1.8363 ± 1.2134   
TNM I-II 54 2.2480 ± 1.3434 −1.749 0.083
  III-IV 71 1.8304 ± 1.3063   
Pathological gradingb I 17 2.2965 ± 1.5570 −1.074 0.345
  II 78 1.8772 ± 1.3135   
  III 30 2.1963 ± 1.2459   
Histological classificationc Adenocarcinoma 101 2.0638 ± 1.3517 4.980 0.008
  Squamous carcinoma 23 1.6222 ± 0.9795   
  Large cell carcinoma 1 5.6000 ± 0.0000   
EGFR amplification No 39 2.0159 ± 1.3763 −0.889 0.378
  Yes 18 1.6533 ± 1.5483   
EGFR protein expression Low 40 2.2843 ± 1.3288 −3.379 0.001
  High 17 1.0006 ± 1.2706   
EGFR mutation Wild type 44 1.9625 ± 1.4570 −0.590 0.557
  Mutationd 13 1.6946 ± 1.3646   
  1. aPaired t student’s test was performed.
  2. bOne-way analysis of variance (ANOVA) test was performed.
  3. cRespective results of comparisons in histological classification were described as below:
  4. Adenocarcinoma vs squamous carcinoma (t = 1.479, P = 0.142).
  5. Adenocarcinoma vs large cell carcinoma (t = −2.603, P = 0.011).
  6. Squamous carcinoma vs large cell carcinoma (t = −3.976, P = 0.001).
  7. dEGFR mutation included short in-frame deletions in exon 19 and point mutations that result in a substitution of arginine for leucine at codon 858 (L858R) in exon 21.