Table 1 Relationship between miR-133a and clinicopathological parameters in NSCLC \( \left(\overline{\mathbf{x}}\pm \mathbf{s}\right) \)

Tissue^a

NSCLC

125

2.0108 ± 1.3334

6.949

<0.001

Adjacent non-cancerous lung

125

3.6430 ± 2.2625

Age (years)

<60

57

1.8321 ± 1.2583

1.377

0.171

≥60

68

2.1606 ± 1.3846

Gender

Male

75

1.9552 ± 1.2893

0.569

0.570

Female

50

2.0942 ± 1.4060

Smoke

No

38

1.7792 ± 1.2891

1.565

0.122

Yes

30

2.3217 ± 1.5689

Tumor size (cm)

≤3 (pT1)

60

2.3058 ± 1.2512

−2.423

0.017

>3 (pT2, pT3, pT4)

65

1.7385 ± 1.3581

Lymph node metastasis

No

56

2.2662 ± 1.3316

−1.951

0.053

Yes

69

1.8035 ± 1.3079

Vascular invasion

No

90

2.0787 ± 1.3777

−0.912

0.364

Yes

35

1.8363 ± 1.2134

TNM

I-II

54

2.2480 ± 1.3434

−1.749

0.083

III-IV

71

1.8304 ± 1.3063

Pathological grading^b

I

17

2.2965 ± 1.5570

−1.074

0.345

II

78

1.8772 ± 1.3135

III

30

2.1963 ± 1.2459

Histological classification^c

Adenocarcinoma

101

2.0638 ± 1.3517

4.980

0.008

Squamous carcinoma

23

1.6222 ± 0.9795

Large cell carcinoma

1

5.6000 ± 0.0000

EGFR amplification

No

39

2.0159 ± 1.3763

−0.889

0.378

Yes

18

1.6533 ± 1.5483

EGFR protein expression

Low

40

2.2843 ± 1.3288

−3.379

0.001

High

17

1.0006 ± 1.2706

EGFR mutation

Wild type

44

1.9625 ± 1.4570

−0.590

0.557

Mutation^d

13

1.6946 ± 1.3646