Fig. 2
From: Hyaluronidase: from clinical applications to molecular and cellular mechanisms
Degradation of dermal hyaluronan by infiltration of hyaluronidase. Dermal fibroblasts play a major role in neo-synthesis of hyaluronan (HA) as an essential component of the extracellular matrix (ECM). The injection of hyaluronidase degrades HA, and subsequently renders the ECM more permeable, resulting in a greater diffusion capacity and bioavailability of injected drugs. In addition, applied hyaluronidase induces the de novo synthesis of HA in dermal fibroblasts to compensate potential transient hyaluronidase-induced HA deficits