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Table 11 Association of Lipid peroxidation (MDA) levels in relation to CYP1A1 and GST gene polymorphisms in NSCLC patients and healthy controls

From: Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India

Gene Genotype Lung cancer patients (MDA levels) p value Controls (MDA levels) p value Total p value
n Mean ± SE n Mean ± SE
CYP1A1 m1 T/T 127 4.18 ± 0.24   138 1.72 ± 0.10   0.01*
  T/C 90 4.21 ± 0.13 <0.01* 98 1.79 ± 0.24 0.42 <0.01*
  C/C 29 4.30 ± 0.13 <0.01* 14 2.00 ± 0.42 0.83 <0.01*
CYP1A1 m2 A/A 73 4.23 ± 0.15   196 1.56 ± 0.11   0.07
  A/G 162 4.22 ± 0.11 0.39 34 1.75 ± 0.23 0.34 0.79
  G/G 11 4.52 ± 0.39 0.87 20 2.12 ± 0.28 0.29 0.86
GSTM1 +/+ 182 4.11 ± 0.10   187 1.73 ± 0.03   <0.01*
  –/– 64 4.60 ± 0.13 0.02* 63 1.95 ± 0.71 0.21 <0.001*
GSTT1 +/+ 200 4.06 ± 0.09   224 1.75 ± 0.29   <0.001*
  –/– 46 5.00 ± 0.20 0.31 26 1.91 ± 0.12 0.09 <0.01*
  1. * p < 0.05