From: Prosthetic joint infection development of an evidence-based diagnostic algorithm
Author | Year | LoE | CoR | (n = x) | Sensitivity | Specificity | Positive predictive value | Negative predictive value | LR for a positive result | LR for a negative result |
---|---|---|---|---|---|---|---|---|---|---|
Barrack et al. | 1993 | I | I | 291 | Â | Â | Â | Â | Â | Â |
 Aspiration culture |  |  |  |  | 0.6 (0.3–0.9) | 0.88 (0.84–0.92) | 0.15 (0.04–0.27) | 0.98 (0.97–1.0) | 5.11 (1.91–11.32) | 0.45 (0.1–0.83) |
Mulcahy et al. | 1996 | I | I | 71 | Â | Â | Â | Â | Â | Â |
 Aspiration culture |  |  |  |  | 0.69 (0.46–0.91) | 0.91 (0.83–0.99) | 0.69 (0.46–0.91) | 0.91 (0.83–0.99) | 7.56 (2.76–61.25) | 0.34 (0.09–0.65) |
Williams et al. | 2004 | I | I | 273 | Â | Â | Â | Â | Â | Â |
 Aspiration culture |  |  |  |  | 0.8 (0.71–0.9) | 0.94 (0.9–0.97) | 0.81 (0.72–0.91) | 0.93 (0.90–0.97) | 12.47 (7.23–29.34) | 0.21 (0.11–0.32) |
Malhotra et al. | 2004 | I | I | 41 | Â | Â | Â | Â | Â | Â |
 Aspiration culture |  |  |  |  | 0.44 (0.12–0.77) | 0.91 (0.81–1.0) | 0.57 (0.2–0.94) | 0.85 (0.73–0.97) | 4.74 (0.62–106.19) | 0.61 (0.23–1.09) |
Schinsky et al. | 2008 | I | I | 201 | Â | Â | Â | Â | Â | Â |
 Wbc (4.2 × 103) |  |  |  |  | 0.84 (0.74–0.93) | 0.93 (0.89–0.97) | 0.82 (0.72–0.92) | 0.94 (0.90–0.98) | 12.21 (6.75–33.94) | 0.18 (0.07–0.29) |
 Neutrophile (80%) |  |  |  |  | 0.82 (0.72–0.92) | 0.83 (0.77–0.89) | 0.64 (0.53–0.76) | 0.92 (0.88–0.97) | 4.78 (3.08–8.36) | 0.22 (0.09–0.37) |
Spanghel et al. | 1999 | I | I | 183 | Â | Â | Â | Â | Â | Â |
 WBC (5.0 × 103) |  |  |  |  | 0.36 (0.18–0.53) | 0.99 (0.98–1.0) | 0.91 (0.74–1.0) | 0.9 (0.85–0.94) | 55.36 (9.43–86.89) | 0.65 (0.46–0.84) |
 Neutrophile (80%) |  |  |  |  | 0.89 (0.78–1.0) | 0.85 (079–0.91) | 0.52 (0.38–0.66) | 0.98 (0.95–1.0) | 5.94 (3.76–10.75) | 0.13 (0.0–0.28) |
Dinneen et al. | 2013 | I | I | 75 | Â | Â | Â | Â | Â | Â |
 WBC (1.58 × 103) |  |  |  |  | 0.895 (0.783–0.997) | 0.913 (0.827–0.999) | n.p. | n.p. | n.p. | n.p. |
 Neutrophile (65%) |  |  |  |  | 0.897 (0.795–0.999) | 0.866 (0.761–0.971) | n.p. | n.p. | n.p. | n.p. |