Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand–foot–mouth disease

Table 2 Dynamic change for serum inflammatory cytokines of NPE and CNSD children patients

Group	Cases	IL-6	TNF-α	IL-4	IL-10	IL-17	IFN-γ
Group NPE
1 day after admission	42	70.56 ± 17.20	58.19 ± 20.67	20.24 ± 5.13	64.11 ± 19.14	55.67 ± 42.18	56.61 ± 10.94
3 days after admission	42	74.80 ± 20.68	52.74 ± 20.22	22.83 ± 3.63	80.14 ± 19.20	53.33 ± 25.22	58.42 ± 9.17
5 days after admission	42	63.73 ± 23.85	30.08 ± 12.20	21.28 ± 4.50	59.92 ± 20.95	48.10 ± 27.22	55.31 ± 8.94
Group CNSD
1 day after admission	47	65.70 ± 18.27	54.57 ± 22.01	19.05 ± 5.78	59.56 ± 22.85	48.14 ± 33.26	48.91 ± 11.73
3 days after admission	47	55.99 ± 13.86	33.57 ± 11.43	20.38 ± 4.54	59.68 ± 16.98	44.81 ± 28.44	53.11 ± 8.96
5 days after admission	47	49.23 ± 13.34	28.92 ± 10.09	19.60 ± 4.54	42.12 ± 16.52	34.29 ± 27.33	45.88 ± 11.06
Value i F_interblock value (P value)		7.855 (0.077)	3.644 (0.042)	4.361 (0.052)	16.823 (0.000)	3.061 (0.084)	20.142 (0.000)
F_time value (P value)		1.876 (0.177)	13.133 (0.001)	0.873 (0.354)	14.580 (0.001)	1.329 (0.254)	3.093 (0.045)
F_interaction value (P value)		2.192 (0.145)	0.2919 (0.592)	0.152 (0.618)	2.612 (0.078)	3.736 (0.059)	0.513 (0.600)

CNSD, central nervous system disease; NPE, neurogenic pulmonary edema; F_interblock value, It refers to the variation (F value) between NPE group and CNSD group; F_time value, it refers to the variation of different time (1, 3, 5 days) about NPE group or CNSD group; F_interaction value, it refers to the interaction variation of group and time. ANOVA of repeated measurement data was used for the statistical test about the comparisons made between or intra-groups

ISSN: 2047-783X