Coenzyme Q10 combined with trimetazidine in the prevention of contrast-induced nephropathy in patients with coronary heart disease complicated with renal dysfunction undergoing elective cardiac catheterization: a randomized control study and in vivo study

Table 5 Effect of CoQ10 and TMZ on oxidative biomarkers in CM-induced acute kidney injury

Groups	Sham control	CM	CM + CoQ10 and TMZ (10 mg/kg)	CM + CoQ10 and TMZ (20 mg/kg)
N	8	8	8	8
GSH (mmol/g tissue)	9.18 ± 1.21	2.69 ± 0.14^#	5.47 ± 0.10*	6.42 ± 0.39*
MDA (nmol/g tissue)	21.5 ± 2.12	61.1 ± 2.34	45.6 ± 2.47*	30.9 ± 3.41**
Catalase (U/mg protien)	10.50 ± 0.68	4.42 ± 0.37^#	6.69 ± 0.52	8.27 ± 0.30**
SOD (U/mg protein)	14.42 ± 0.48	7.36 ± 1.53^#	10.49 ± 0.54*	12.55 ± 0.76*

^#p < 0.05, compared with sham control; * p < 0.05, ** p < 0.01, compared with CM model group

ISSN: 2047-783X