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Table 1 Sixth and seventh editions of the AJCC/UICC TNM classification algorithm for intrahepatic cholangiocarcinoma (ICC)

From: Comparison of the sixth and the seventh editions of the UICC classification for intrahepatic cholangiocarcinoma

  Sixth edition   Seventh edition
T1 Solitary tumor without vascular invasion T1 Solitary tumor without vascular invasion
T2 Solitary tumor with vascular invasion or multiple tumors, none more than 5 cm T2a Solitary tumor with vascular invasion
   T2b Multiple tumors, with or without vascular invasion
T3 Multiple tumors more than 5 cm or tumor involving a major branch of the portal or hepatic veins T3 Tumor(s) perforating the visceral peritoneum or direct extension to extrahepatic structures
T4 Tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum T4 Tumor with periductal invasion
N0 No regional lymph node metastases N0 No regional lymph node metastases
N1 Regional lymph node metastases N1 Regional lymph node metastases
M0 No distant metastases M0 No distant metastases
M1 Distant metastases M1 Distant metastases
Stage   Stage  
I T1 N0 M0 I T1 N0 M0
II T2 N0 M0 II T2 N0 M0
IIIa T3 N0 M0 III T3 N0 M0
IIIb T4 N0 M0   
IIIc Any T, N1 M0   
IV Any T, Any N, M1 IVa T4 N0 M0, Any T N1 M0
   IVb Any T, Any N, M1