Table 1 Sixth and seventh editions of the AJCC/UICC TNM classification algorithm for intrahepatic cholangiocarcinoma (ICC)
Sixth edition | Seventh edition | ||
|---|---|---|---|
T1 | Solitary tumor without vascular invasion | T1 | Solitary tumor without vascular invasion |
T2 | Solitary tumor with vascular invasion or multiple tumors, none more than 5 cm | T2a | Solitary tumor with vascular invasion |
T2b | Multiple tumors, with or without vascular invasion | ||
T3 | Multiple tumors more than 5 cm or tumor involving a major branch of the portal or hepatic veins | T3 | Tumor(s) perforating the visceral peritoneum or direct extension to extrahepatic structures |
T4 | Tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum | T4 | Tumor with periductal invasion |
N0 | No regional lymph node metastases | N0 | No regional lymph node metastases |
N1 | Regional lymph node metastases | N1 | Regional lymph node metastases |
M0 | No distant metastases | M0 | No distant metastases |
M1 | Distant metastases | M1 | Distant metastases |
Stage | Stage | ||
|---|---|---|---|
I | T1 N0 M0 | I | T1 N0 M0 |
II | T2 N0 M0 | II | T2 N0 M0 |
IIIa | T3 N0 M0 | III | T3 N0 M0 |
IIIb | T4 N0 M0 | ||
IIIc | Any T, N1 M0 | ||
IV | Any T, Any N, M1 | IVa | T4 N0 M0, Any T N1 M0 |
IVb | Any T, Any N, M1 |