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Table 1 Most relevant PIMs in orthogeriatric setting

From: Orthogeriatric treatment reduces potential inappropriate medication in older trauma patients: a retrospective, dual-center study comparing conventional trauma care and co-managed treatment

Drug Reason
(Ibuprofen, Diclofenac, Aspirin)
Increased risk for: gastrointestinal ulcer, myocardial infarction (MI), stroke, hypertensive crisis, impaired renal function
Benzodiazepines Increased risk for sedation, delirium, falls
Tricyclic antidepressants at preexisting dementia Increased risk for delirium, falls, urinary retention, cardiac arrythmia
Opiates (long acting) at preexisting dementia Cognitive worsening
Antimuscarinic drugs at preexisting dementia Cognitive worsening
Neuroleptics (long acting) at preexisting Parkinson´s disease Cognitive worsening
SSRI-type antidepressants at hyponatremia Cognitive worsening, increased risk of falls, negative effect on bone metabolism
 Gyrase inhibitors
Increased risk for:
 QT extension, seizure, dizziness, confusion, tendon rupture
 Renal failure, ototoxicity
Antihistamines (especially H1) Increased risk for: constipation, dizziness, cognitive impairment
Statins (except at preexisting MI, coronary heart disease, stroke) Muscle weakness, increased risk for rhabdomyolysis
Urologicals/incontinence medication (except indispensable) Increased risk for: cognitive worsening, falls
Glucocorticoids (except indispensable) Confusion, negative effect on bone metabolism
Digitalis (except indispensable) Cardiac arrythmia
Diuretics (except indispensable, e.g., at renal insufficiency) Increased risk for: dizziness, dehydration, confusion, electrolyte imbalance
Specific antihypertensive drugs (clonidine, reserpine, propranolol, hydralazine) Increased risk for: cognitive impairment, depression, orthostatic hypotension, sedation