Table 1 The conserved genes differentially expressed in both GSE97320 and GSE66360

3.715416803

0.000290322

2.319993166

< 0.0001

2.19001047

0.003256902

2.383412763

< 0.0001

3.760092992

0.004065492

2.468096374

< 0.0001

1.877766083

0.001336775

1.757327328

< 0.0001

1.931964423

0.000341343

2.848042441

< 0.0001

3.421860496

0.017438642

1.458088512

< 0.0001

0.891511885

0.011998793

1.376148893

< 0.0001

1.879835689

0.003477466

1.718774941

< 0.0001

3.149278731

0.005306621

2.412986325

< 0.0001

2.250309635

0.000500285

1.859238466

< 0.0001

2.145806047

0.006632287

2.515427476

< 0.0001

0.830570678

0.047479898

1.888141317

< 0.0001

2.073315077

0.0000438

1.138660839

< 0.0001

1.806072308

0.000219741

1.400798053

< 0.0001

1.306346402

0.01467501

1.270678227

< 0.0001

1.68182951

0.018260863

1.989220351

< 0.0001

2.764547251

0.000328017

1.271651227

< 0.0001

− 1.202805686

0.027261213

− 1.682690294

< 0.0001

1.212871872

0.043664444

1.254857254

< 0.0001

0.765865504

0.038125016

0.778311524

< 0.0001

0.660265341

0.016856452

1.605988515

< 0.0001

1.232389286

0.029795796

2.187724267

< 0.0001

3.878586998

0.0000872

1.638136049

< 0.0001

2.085892271

0.01667478

2.001432298

< 0.0001

1.310855377

0.017420794

1.215915653

< 0.0001

3.9607872

0.018922169

1.064428591

< 0.0001

3.004222492

0.000922447

1.282605825

< 0.0001

0.941442135

0.008081851

2.138155827

< 0.0001

1.388152953

0.003229592

1.15652044

< 0.0001

2.06910398

0.000914725

1.461369096

< 0.0001

1.606678644

0.004965952

1.126718923

< 0.0001

2.769525669

0.00898907

1.485180438

< 0.0001

2.679234011

0.00045788

1.121985648

< 0.0001

1.359533482

0.04082833

1.408576461

< 0.0001

1.518215926

0.002104306

1.698436828

< 0.0001

1.442005776

0.00017885

0.863524366

< 0.0001

0.729995143

0.019983292

1.394025803

< 0.0001

− 0.566509776

0.049459364

− 0.737136085

< 0.0001

1.502206913

0.019743677

2.603791299

< 0.0001

− 0.776384955

0.01829638

− 1.95935621

< 0.0001

0.743728715

0.026751653

1.711115656

< 0.0001

2.866177199

0.00943438

2.053476388

< 0.0001

0.969762074

0.005618694

0.949529005

< 0.0001

1.939542124

0.003227223

1.238799783

< 0.0001

1.597284132

0.013637632

2.179973359

< 0.0001

3.058858412

0.001506307

1.61933339

< 0.0001

1.254827529

0.021198075

1.110084724

< 0.0001

1.387185414

0.026898778

0.997833095

< 0.0001

1.008783969

0.022408169

1.453545191

< 0.0001

1.325609511

0.01449473

1.356511126

< 0.0001

− 1.181499024

0.028794617

− 1.616668145

< 0.0001

1.008366932

0.02131624

1.146286395

< 0.0001

− 0.480686383

0.027928556

− 1.236804343

< 0.0001

2.154977188

0.007550323

1.297242172

< 0.0001

1.230745211

0.02057251

1.972782405

< 0.0001

1.528052824

0.001923619

1.00822514

< 0.0001

2.10709958

0.000256162

0.906661034

< 0.0001

0.944951526

0.002191432

0.714960381

< 0.0001

0.958109791

0.012432822

1.460308619

< 0.0001

1.272631449

0.00994245

1.148478416

< 0.0001

2.333240109

0.018284882

2.131747969

< 0.0001

2.824751704

0.00472807

2.110183937

< 0.0001

1.402640902

0.028502087

1.074225506

< 0.0001

− 0.707207366

0.016384142

− 1.043483941

< 0.0001

0.66281941

0.024585326

0.754981016

< 0.0001

− 0.835067476

0.045419126

− 1.223531516

< 0.0001

1.943399108

0.021464182

1.895503232

< 0.0001

− 0.721354352

0.048955977

1.614895577

< 0.0001

2.199274247

0.02941438

1.600783776

< 0.0001

0.821859648

0.048035987

1.078872501

< 0.0001

1.697322241

0.023704466

1.022277137

< 0.0001

1.209440706

0.015391784

0.84564545

< 0.0001

1.606386641

0.007085751

1.505836542

< 0.0001

1.588575564

0.040614788

0.966784955

< 0.0001

1.467435961

0.002424106

0.883668576

< 0.0001

0.672547012

0.025451375

1.354276298

< 0.0001

− 1.247490335

0.000854948

− 1.105178815

< 0.0001

1.563752908

0.000217748

0.815993132

< 0.0001

2.613026128

0.003928869

1.549771356

< 0.0001

0.819452437

0.024240235

0.847572886

< 0.0001

1.989921497

0.025319691

1.582056104

< 0.0001

2.973441365

0.000645968

1.446062497

< 0.0001

2.386813879

0.000921878

1.23662014

< 0.0001

1.780855138

0.011714132

1.024539916

< 0.0001

1.596394305

0.001901717

0.889101647

< 0.0001

2.447756683

0.000438167

0.644662214

< 0.0001

1.3493504

0.007738217

1.042625117

< 0.0001

0.674899289

0.031132314

0.803066827

< 0.0001

0.47497249

0.043443589

1.235734387

< 0.0001

− 0.846155897

0.006163145

− 1.330967712

< 0.0001

− 1.126543214

0.013735129

− 0.871863341

< 0.0001

3.222121

0.005523564

0.868185585

< 0.0001

2.697015762

0.017524244

1.18798994

< 0.0001

0.907871679

0.001791958

1.849318307

< 0.0001

1.44935076

0.039373731

1.457675515

< 0.0001

1.098874935

0.039814237

0.508070689

< 0.0001

− 0.694870463

0.04616438

− 1.433351491

< 0.0001

− 0.985252239

0.036510489

− 1.167389496

< 0.0001

1.901669081

0.000154316

0.565073179

< 0.0001

1.702264526

0.018461448

0.915025557

< 0.0001

1.785779636

0.00034891

0.657209785

< 0.0001

− 0.91504058

0.032471404

− 1.324336977

< 0.0001

− 0.538426791

0.036659702

− 1.414883543

< 0.0001

2.276317524

0.047321026

1.137294855

< 0.0001

1.078051413

0.032816176

0.835988452

< 0.0001

0.735179941

0.03520765

0.727680923

0.000101662

0.969302605

0.032765571

1.798031132

0.000102992

1.351200785

0.00167848

0.585528821

0.000107046

1.085019322

0.010168639

0.715711002

0.000108507

0.70475403

0.01525679

0.91961625

0.000111858

− 1.47500487

0.046026587

− 1.57933263

0.000112299

− 1.181714286

0.010168237

− 0.87301352

0.000115697

1.988784507

0.016690641

0.687475626

0.000115702

1.28311422

0.009728893

0.796509712

0.000120788

1.709600858

0.0003786

0.756754733

0.000121731

1.012045755

0.00547019

0.525968344

0.000127289

3.02456454

0.003699774

1.099434156

0.000129507

2.180194614

0.0109879

1.397451606

0.00013196

− 1.252002755

0.000726559

− 0.787841536

0.000138471

− 0.703607148

0.008657374

− 0.818610782

0.000149306

0.85182211

0.047333209

0.936460647

0.000150743

3.213431913

0.005317158

1.610096737

0.000154249

1.239490617

0.006173363

0.732825202

0.000169972

1.346013773

0.005411258

1.029764841

0.000170653

0.967130969

0.003641179

0.77481882

0.000179849

1.291691746

0.017168802

1.307076894

0.000180583

− 1.237598849

0.038502248

− 1.525016605

0.000185774

1.773187189

0.000256431

0.833485867

0.000189348

2.200868771

0.008362239

1.631201272

0.000194977

1.898237252

0.010803144

0.694482086

0.000198083

1.556044518

0.003364024

0.596626207

0.000203962

1.731770541

0.002114113

0.512674471

0.000205394

0.660538961

0.039295856

0.702552153

0.000224265

1.263612775

0.018980734

1.063744226

0.000232443

− 1.021874256

0.010996345

− 0.986409189

0.000239356

1.133988939

0.002525393

0.812308902

0.000251335

0.509987239

0.029154597

0.733979649

0.000260216

− 0.690969237

0.034617547

− 1.158028865

0.000264123

3.813483966

0.008808688

1.227532333

0.000268305

1.165012649

0.015051532

0.902135148

0.000293066

1.510242008

0.044692504

1.262470054

0.000312948

− 1.110993329

0.02752944

− 0.993962406

0.00034754

− 0.696898862

0.030343011

− 0.929231267

0.00036119

− 0.522846432

0.034922941

− 0.859607844

0.000415198

− 1.283202812

0.04751078

− 1.223608639

0.000416573

− 0.838180298

0.021768338

− 1.025353413

0.000421081

1.242116323

0.025822193

0.852205923

0.000421285

− 0.985373014

0.031611917

− 1.13057002

0.000441549

1.634772394

0.016110753

1.070768411

0.000443755

1.430929047

0.019642805

1.517379129

0.000445953

2.891652429

0.012098196

1.083712332

0.000464153

− 0.527154589

0.03711239

− 0.703895685

0.000466123

2.939399055

0.036736625

0.868766712

0.000480117

− 2.085425559

0.00830834

− 0.92642157

0.000481112

− 0.889975527

0.007382474

− 0.591810379

0.000482869

0.833331837

0.013979206

0.872451565

0.00048829

− 1.536179035

0.00212696

− 1.388394318

0.000503169

0.970662172

0.03919739

0.464432831

0.000516733

0.566964411

0.027129826

0.45352211

0.000530533

− 0.994967054

0.005926672

− 0.720422053

0.000556354

0.677302641

0.00863392

0.949974076

0.000560322

1.459070601

0.002685799

0.818145005

0.000567591

1.900952269

0.006990223

0.648074395

0.000590111

0.785725374

0.033763579

0.870706647

0.000608321

1.15374636

0.024380781

0.457987789

0.000610161

0.790715098

0.028493908

0.594190441

0.000620025

1.277853147

0.005001915

0.975255592

0.000625103

− 0.962891471

0.001294926

− 0.810866571

0.000673172

0.84100527

0.038963808

0.771737601

0.000685328

− 0.572880851

0.02337171

− 0.794559375

0.000695958

1.303124037

0.013360086

1.017612578

0.000703371

− 0.869517958

0.043390346

− 1.019489489

0.00070353

− 0.90413844

0.041510611

− 0.80325959

0.000756448

2.441007592

0.01581582

0.97531267

0.000777516

0.855445347

0.038108625

0.783883625

0.000784817

− 0.81533148

0.005926379

− 0.854080807

0.000803216

− 0.933289637

0.006719525

− 1.081765186

0.000832872

0.844767801

0.034723888

0.610479487

0.00088448

1.363565695

0.045081671

0.806155508

0.000897176

1.332152673

0.000181302

0.703062789

0.00092457

1.376479024

0.015121968

0.783168056

0.000935223

0.901392581

0.035582908

0.72491305

0.000938466

− 1.15942957

0.001304937

− 1.10912258

0.000951423

− 1.016071403

0.025599739

− 1.17719563

0.000962182

1.293690918

0.001559527

0.617592666

0.000979709

1.337085004

0.024622123

0.789355603

0.001035706

1.798309942

0.003199858

0.549277047

0.001044485

− 0.974081458

0.026063953

− 1.280741756

0.001082083

1.151105372

0.000612836

1.667435842

0.00114641

1.528578408

0.022982592

1.145057625

0.001148462

0.786226017

0.04583837

0.646827746

0.001155134

− 0.911262187

0.006347222

− 0.708906078

0.001168614

3.054926626

0.007540706

1.110136702

0.001188049

0.913892454

0.003039259

0.770873995

0.001243107

1.098421547

0.005150015

0.754043428

0.00125101

− 0.839086258

0.031308986

− 0.849482287

0.001277728

− 1.345332297

0.013596272

− 0.969000288

0.001316741

2.350439432

0.001568506

1.426523404

0.001319682

− 0.808285785

0.036923826

− 0.594491349

0.001339096

− 2.184588821

0.040088141

− 0.93615243

0.001361012

− 1.155228734

0.013040415

− 0.518495367

0.001376683

− 0.929412935

0.006056463

− 0.913154729

0.001399971

2.102229556

0.000178319

0.841794717

0.001410075

− 1.40383474

0.007805487

− 0.735973926

0.001444816

− 0.779793242

0.021017904

1.086712809

0.001468786

1.60229352

0.038415425

0.716082883

0.001490739

0.98658481

0.010627222

0.567380206

0.001504916

1.349039117

0.020807799

0.513207382

0.001520858

1.538740411

0.040216887

0.502710942

0.001523024

2.636101881

0.004536708

0.494696947

0.00155925

1.445983931

0.004029835

0.552945436

0.001562541

1.014160119

0.002281996

0.717868982

0.001606081

− 1.365943289

0.001327507

− 0.595216422

0.001625267

3.247649892

0.0000955

0.478498353

0.001735362

0.778394075

0.009116649

0.636669015

0.001778326

− 1.430887468

0.002003066

− 0.913772788

0.0018777

− 1.721065936

0.009279288

− 0.835575098

0.001927602

− 0.505724162

0.044175513

− 0.997261329

0.00197887

0.915484027

0.029789731

0.839308791

0.002037968

0.713528467

0.026268016

0.661229341

0.002047801

− 0.754993386

0.025500124

− 0.973299711

0.002076982

0.652023956

0.030611426

0.728288754

0.002160493

2.292398494

0.033636936

0.623649579

0.002172112

− 1.165387619

0.00087698

− 0.539399165

0.002174586

4.365021825

0.003169993

0.52927351

0.002242851

1.693282707

0.006494326

0.482795744

0.002365768

1.896513739

0.011966121

1.008557895

0.00237302

0.721676035

0.006408239

1.182091335

0.002417955

1.861941801

0.004174164

0.544068211

0.002425819

1.851219504

0.008897467

1.254434919

0.002493206

− 1.011979188

0.035057218

− 0.710888004

0.002503157

− 1.418751894

0.021858458

− 0.821318547

0.002526554

1.494672795

0.000190407

0.666636746

0.002625559

1.43259319

0.038940531

0.546212963

0.002633285

− 0.610227552

0.041831331

− 0.803569365

0.002640731

0.605142119

0.044216485

0.486955837

0.002659029

3.012960368

0.048869583

0.503342235

0.002691189

− 1.418926748

0.043956086

− 0.740787553

0.002719864

1.756451065

0.026679736

0.924004639

0.002740384

2.053694233

0.000197952

0.451082876

0.002771411

1.38976538

0.010674237

0.849343314

0.002942074

2.840950381

0.005912694

1.108939843

0.002978094

− 1.48967097

0.03404748

− 1.014128699

0.003062724

0.531042713

0.021090503

0.459089464

0.003165946

1.201422325

0.005387136

0.46795845

0.003218277

− 0.83937625

0.024109007

− 0.565184788

0.003355533

1.745352413

0.013173346

0.799248122

0.003376755

− 0.772923097

0.032500554

− 0.505466721

0.003452495

0.569547478

0.038813449

0.535246343

0.003585976

1.784627427

0.001016962

0.678723979

0.003615633

− 0.524011745

0.033009479

− 0.878657539

0.003617168

1.718120007

0.003180389

0.644368871

0.003635816

− 1.845504585

0.008969037

− 1.193440354

0.003699308

− 1.050961105

0.014574394

− 0.80126366

0.003700902

1.321414802

0.006004518

0.738209029

0.003701828

2.816842846

0.00000849

0.466923422

0.003713308

1.137141559

0.044765741

0.758160268

0.003753251

1.794885166

0.00447288

0.579182361

0.003765784

1.188903575

0.004557879

0.581780349

0.003843326

− 0.669519886

0.031226669

− 0.585698567

0.00386508

− 0.607349146

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