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Table 2 Univariate and multivariate analyses for DSS for patients identified in the SEER Program database from 1973 to 2013

From: Clinical characteristics associated with primary cardiac angiosarcoma outcomes: a surveillance, epidemiology and end result analysis

Factors Category Univariate analysis Multivariable analysis
HR 95% CI P value HR 95% CI P value
Age < 45/≥ 45 1.793 1.284–2.504 0.001 2.165 1.475–3.179 0.000
Race White    0.936    0.162
Black 0.982 0.640–1.506 0.934 1.478 0.904–2.414 0.119
Other 0.913 0.558–1.494 0.717 0.807 0.469–1.389 0.439
Histological grade Well    0.476    0.839
Moderate 1.232 0.128–11.849 0.857 0.575 0.029–11.410 0.717
Poor 2.604 0.347–19.527 0.352 1.889 0.209–17.053 0.571
Undifferentiated 2.158 0.289–16.127 0.454 1.632 0.175–15.215 0.667
Unknown 2.741 0.377–19.920 0.319 1.711 0.200–14.664 0.624
TNM stage I    0.234    0.056
II 0.584 0.123–2.771 0.498 0.386 0.026–5.760 0.490
III 0.238 0.047–1.190 0.080 0.104 0.007–1.554 0.101
IV 0.390 0.094–1.627 0.196 0.130 0.007–2.485 0.175
Unknown 0.488 0.119–1.999 0.318 0.102 0.007–2.390 0.087
Tumour size < 3 cm    0.001    0.026
3–5 cm 1.673 0.635–4.406 0.297 1.955 0.698–5.475 0.202
> 5 cm 2.049 0.812–5.170 0.129 3.182 1.149–8.809 0.026
Unknown 3.572 1.425–8.953 0.007 3.878 1.387–10.841 0.010
LN metastases No    0.126    0.730
Yes 1.332 0.697–2.546 0.386 1.390 0.592–3.264 0.449
Unknown 1.430 1.010–2.024 0.044 0.946 0.337–2.651 0.916
Distant metastases No    0.157    0.372
Yes 0.985 0.617–1.571 0.948 0.385 0.077–1.922 0.244
Unknown 1.374 0.907–2.081 0.134 1.571 0.474–5.210 0.460
Radiation Yes/no, unknown 1.751 1.053–2.911 0.031 1.629 1.049–2.529 0.030
Surgery Yes/no, unknown 1.442 1.034–2.011 0.031 1.427 0.946–2.153 0.090
Summary stage Localized    0.172    0.008
Regional 0.691 0.44–1.086 0.109 0.771 0.422–1.410 0.399
Distant 0.676 0.456–1.004 0.052 1.819 0.964–3.433 0.065
Unstaged 0.656 0.161–2.678 0.557 0.294 0.063–1.363 0.118