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Table 2 Detailed clinical, demographic and molecular characteristics of 42 M. tuberculosis isolates in 16 (Cluster I to Cluster XVI) clusters

From: Correction to: Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB

Cluster no.Clinica specimenIsolate no.Year of isolationPatient’s nationalitySpoligotyping dataGenetic alteration detected in
SITMtb familyrpoBkatGinhApncAembBrpsLrrsgidBrpsA
ISputumKM06-1532006Indian255BeijingTCG456TTGACG315ACCWTWTATG306GTGAAG43AGGWTN. D.N. D.
CSFKM09-222009Indian255BeijingTCG456TTGACG315ACCWTWTATG306GTGAAG43AGGWTN. D.N. D.
SputumKM13-372013Indian1BeijingTCG456TTGACG315ACCWTWTATG306GTGAAG43AGGWTN. D.N. D.
FNAKM16-062016Nepalese1BeijingTCG456TTGACG315ACCWTWTATG306GTGAAG43AGGWTN. D.N. D.
FNAKM17-032017Indian1BeijingTCG456TTGACG315ACCWTWTATG306GTGAAG43AGGWTN. D.N. D.
IISputumKM14-582014Nepalese1BeijingTCG456TTGACG315ACCWTGTG139GCGATG306GTGAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
SputumKM14-692014Indian1BeijingTCG456TTGACG315ACCWTGTG139GCGATG306GTGAAG43AGGWTGCA205GCGWT
IIISputumKM08-5012008Kuwaiti1BeijingTCG456TTGACG315ACCWTGGT139GTTATG306GTGAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
SputumKM08-5022008Kuwaiti1BeijingTCG456TTGACG315ACCWTGGT139GTTATG306GTGAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
SputumKM09-2072009Indian1BeijingTCG456TTGACG315ACCWTGGT139GTTATG306GTGAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
IVSputumKM12-052012Ethiopian21CAS1-KiliTCG456TTGACG315ACCWTIns193A (FS) + TCC65TCTATG306GTGAAG88AGGWTN. D.N. D.
SputumKM12-172012Ethiopian1144T1TCG456TTGACG315ACCWTIns193A (FS) + TCC65TCTATG306GTGAAG88AGGWTN. D.N. D.
SputumKM15-082015Ethiopian21CAS1-KiliTCG456TTGACG315ACCWTIns193A (FS) + TCC65TCTATG306GTGAAG88AGGWTN. D.N. D.
VSputumKM07-3332007IndonesianOrphanN. A.TCG456TTGACG315ACCWTWTWTWTWTN. D.N. D.
SputumKM10-232010Indian355EAI3-INDTCG456TTGACG315ACCWTWTWTWTWTN. D.N. D.
VISputumKM07-2932007Filipino194LAM2TCG456TTGACG315ACCWTWTCAG497CGGWTWTN. D.N. D.
SputumKM12-012012Filipino25CAS1-DelhiTCG456TTGACG315ACCWTWTCAG497CGGWTWTN. D.N. D.
VIISputumKM09-2022009Ethiopian47H1GTC176TTCACG315ACCWTWTWTWTWTN. D.N. D.
SputumKM15-172015Indian47H1GTC176TTCACG315ACCWTWTWTWTWTN. D.N. D.
VIIISputumKM14-672014Ethiopian149T3-ETHTCG456TTGACG315ACCWT− 11 A/GATG306ATCWTWTGGT69GATWT
SputumKM15-212015Ethiopian149T3-ETHTCG456TTGACG315ACCWT− 11 A/GATG306ATCWTWTGGT69GATWT
IXSputumKM07-2832007Indian26CAS1-DelhiTCG456TTGACG315ACCWTTCC65TCTATG306ATAWTWTN. D.N. D.
SputumKM14-682014IndianOrphanN. A.TCG456TTGACG315ACCWTTCC65TCTATG306ATAWTWTN. D.N. D.
SputumKM17-202017Kuwaiti1BeijingTCG456TTGACG315ACCWT− 11 A/GCAG497CGGAAG43AGGWTGAA92GAC + GCA205GCGWT
XSputumKM17-222017Kuwaiti1BeijingTCG456TTGACG315ACCWT− 11 A/GCAG497CGGAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
SputumKM17-732017Indian1BeijingTCG456TTGACG315ACCWT− 11 A/GCAG497CGGAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
PusKM11-5032011Kuwaiti1BeijingTCG456TTGACG315ACCWT− 11 A/GGGC406GACAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
SputumKM14-562014Kuwaiti1BeijingTCG456TTGACG315ACCWT− 11 A/GGGC406GACAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
XISputumKM15-132015Kuwaiti1BeijingTCG456TTGACG315ACCWT− 11 A/GGGC406GACAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
SputumKM15-262015Kuwaiti1BeijingTCG456TTGACG315ACCWT− 11 A/GGGC406GACAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
SputumKM17-022015Kuwaiti1BeijingTCG456TTGACG315ACCWT− 11 A/GGGC406GACAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
SputumKM17-692017Kuwaiti1BeijingTCG456TTGACG315ACCWT− 11 A/GGGC406GACAAG43AGGWTGAA92GAC + GCA205GCGCGA212CGC
XIISputumKM16-322016Egyptian19EAI2-ManilaCAC451TACACG315ACC− 15 C/TGAA37AAACTG355CTA + GAG378GCGWTWTGTG110GTT + GCA205GCGWT
SputumKM17-012017Filipino19EAI2-ManilaCAC451TACACG315ACC− 15 C/TGAA37AAACTG355CTA + GAG378GCGWTWTCTC59TTC + GTG110GTT + GCA205GCGWT
XIIIPusKM07-2972007IndianOrphanN. A.CAC451GACWT− 15 C/TTCC65TCG + Ins 453T (FS)ATG306CTGWTWTN. D.N. D.
FNAKM11-5022015Indian3361T1CAC451GACWT− 15 C/TTCC65TCG + Ins 453T (FS)ATG306CTGWTWTN. D.N. D.
XIVSputumKM06-482006Egyptian53T1TCG456TTGWT− 15 C/TWTWTWTWTN. D.N. D.
TissueKM06-2772006Filipino19EAI2-ManilaTCG456TTGWT− 15 C/TWTWTWTWTN. D.N. D.
XVSputumKM16-332016Indian8EAI3/EAI5CAC451TACACG315ACCWTCTG35CCGATG306GTG + GAG378GCGAAG43AGGWTGTG110GTT + GCA205GCGWT
SputumKM17-062017Filipino8EAI3/EAI5CAC451TACACG315ACCWTCTG35CCGATG306GTG + GAG378GCGAAG43AGGWTGTG110GTT + GCA205GCGWT
XVISputumKM07-2312007IndianOrphanaCAS1-DelhiATG440ATA + GAC441TACACG315ACCWTTCC65TCTGGC406TGCWTWTGCA205GCG + Del 350G (FS)WT
SputumKM07-2522007SyrianOrphanaCAS1-DelhiATG440ATA + GAC441TACACG315ACCWTTCC65TCTGGC406TGCWTWTGCA205GCG + Del 350G (FS)WT
  1. Clusters containing MDR-TB strains with identical patterns and isolated within a period of nearly 2 years are shown as underlined. Synonymous mutations are italicized
  2. N. A., not applicable; N. D., not done; CSF, cerebrospinal fluid; FNA, fine needle aspirate; SIT, shared international type; Mtb family, M. tuberculosis family; WT, wild-type sequence; Ins, insertion mutation; (FS), frame shift mutation, fine needle aspirate
  3. aBoth isolates displayed identical spoligotyping pattern