Table 1 Summary of surgical methods applied to achieve bone healing prior to utilization of an individual healing attempt with a tissue-engineered construct including a medical-grade polycaprolactone and tricalcium phosphate scaffold
Time after trauma | Diagnosis | Surgical treatment |
|---|---|---|
 + 6 weeks | Local infection with multi-resistant Gram-negative Escherichia coli with intramedullary nail (IMN) in situ | Procedural change to external fixation and Masquelet technique with vancomycin-loaded cement spacer |
 + 10 weeks | Critical-size femoral defect with established Masquelet induced membrane | IMN fixation and Reamer–Irrigator–Aspirator® (RIA) bone grafting mixed with Cerament G® |
 + 14 months | Persistent pain and non-union | Insertion tricortical iliac crest graft (lateral aspect of femur) with Cerament G® and secured with additional plate |
 + 21 months | Resorption of tricortical iliac crest graft and ongoing pain during loadbearing | Implantation of patient-specific medical-grade scaffold in combination with autologous bone graft and bone morphogenetic protein-2 |