From: ANCA-associated vasculitis overlaps with systemic sclerosis: a case report and literature review
SSc + AGN | SRC | |
---|---|---|
Disease duration | Long, > 4 years | Short, 1–4 years |
Characteristic autoantibody | Anti-MPO, anti-PR3 | Anti-RNA polymerase III |
Anti-SCL-70 antibody | Common (58.8–76%) | Uncommon (21%) |
Blood pressure | Normal or slightly higher | Malignant hypertension |
Urine protein | Excessive urine protein (red blood cell cast) | Urine protein < 1 g/24 h |
Renal biopsy | Crescent formation | Arterial intimal thickening, thrombosis, fibrinoid necrosis, glomerulosclerosis |
Prognosis | Rapid progress and high mortality | High rate of renal replacement therapy |