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Table 2 Clinicopathological characteristics of patients in MGRS group

From: Clinicopathological characteristics of patients with paraproteinemia and renal damage

  Amyloidosis (n  =  25) Cryo-GN (n  =  7) MIDD (n  =  3) PGNMID (n  =  5) P value
Male [n (%)] 17 (68.0) 4 (57.1) 2 (66.7) 2 (38.1) 0.336
Age (year) 58.0  ±  7.7 53.3  ±  16.4 69.7  ±  8.4 56.4  ±  7.5 0.209
Renal disease duration before renal biopsy (months) 10.0  ±  10.8 7.8  ±  7.0 22.0  ±  22.7 13.7  ±  10.3 0.289
Hematuria [n (%)] 2 (23)a,c 6 (85.7) 1 (33.3) 3 (60.0) 0.001
Proteinuria (g/24 h) 3.8  ±  2.3 7.0  ±  2.9a,d,e 2.0  ±  1.6 2.1  ±  1.5 0.002
Albumin (g/L) 25.8  ±  5.8 25.4  ±  3.9 36.6  ±  1.7b,d 31.1  ±  9.7 0.017
Hemoglobin (g/L) 123.4  ±  16.5a,b,c 91.1  ±  12.5 93.0  ±  28.2 104.6  ±  16.5 0.000
SCr (μmol/L) 134.2  ±  216.8 243.3  ±  197.3 386.3  ±  221.0b,f 78.6  ±  33.1e 0.002
eGFR (mL/min/1.73m2) 81.7  ±  37.6 29.0  ±  17.1a,e 18.4  ±  10.7 b,f 80.1  ±  30.4 0.001
Low serum C3 [n (%)] 4 (16.0)c 3 (42.9) 2 (66.7) 5 (100) 0.089
Abnormal serum κ/λ ratio [n (%)] 13 (52.0) 3 (42.9) 2 (66.7) 0 (0) 0.269
Abnormal urine κ/λ ratio [n (%)] 14 (60.9) 1 (14.3) 2 (66.7) 0 (0) 0.131
Abnormal sIFE [n (%)] 16 (66.7) 5 (71.4) 2 (66.7) 1 (20) 0.237
Abnormal uIFE [n (%)] 17 (77.3) 3 (75) 2 (100) 1 (50) 0.702
κ (sIFE, [n (%)]) 3 (20.0)a 4 (80) 1 (50) 0 (0) 0.031
κ (uIFE, [n (%)]) 3 (18.8) 1 (33.3) 1 (50.0) 0 (0) 0.687
Renal monotypic κ [n (%)] 4 (16.0)c 5 (71.4) 2 (66.7) 4 (80) 0.003
Global glomerulosclerosis (%) 14.4  ±  16.4 17.4  ±  22.8 42.3  ±  13.7b,d,f 12.6  ±  13.8 0.081
Segmental glomerulosclerosis (%) 0 3.1  ±  8.3 0 2  ±  4.5 0.236
Crescents (%) 0 18.0  ±  32.2a 0 8.2  ±  6.8 0.319
IFTA 1.04  ±  0.69a 1.86  ±  0.69e 3.0  ±  0.0b,d,f 1.0  ±  0.0 0.000
Interstitial inflammation 0.79  ±  0.66a,b 2.14  ±  0.69 2.33  ±  0.58 1.40  ±  0.89 0.000
Podocyte effacement (%) 2.6  ±  0.6 2.6  ±  0.8 2.3  ±  0.6 2.4  ±  0.9 0.883
  1. MGRS monoclonal gammopathy of renal significance; MM multiple myeloma; MGUS monoclonal gammopathy of undetermined significance; MIg monoclonal immunoglobulin; monoIg monotypic immunoglobulin; SCr serum creatinine; eGFR the estimated glomerular filtration rate; sIFE serum immunofixation electrophoresis; uIFE urine immunofixation electrophoresis; IFTA interstitial fibrosis/tubular atrophy
  2. aP  <  0.05, Amyloid vs Cryo group
  3. bP  <  0.05, Amyloid vs MIDD group
  4. cP  <  0.05, Amyloid vs PGNMID group
  5. dP  <  0.05, Cryo vs MIDD group
  6. eP  <  0.05, Cryo vs PGNMID group
  7. fP  <  0.05, MIDD vs PGNMID group