Fig. 2
From: Successful treatment of acquired reactive perforating collagenosis with itraconazole
a Lesional skin biopsy showing a cup-shaped depression plugged with necrotic inflammatory debris (haematoxylin and eosin staining [H&E] × 40). b The central crusted keratotic plug contains keratin, cellular debris, and fibrous tissue (H&E × 200). c van Gieson staining (original magnification ×40) showing elimination of fibrous tissue through the dermis into the epidermis. d No fungal hyphae were found on periodic acid–Schiff staining (original magnification ×100). e Gomori’s methenamine silver staining shows the transepidermal fibres and the absence of fungi (original magnification ×100)