The efficacy and safety of high-flow nasal cannula therapy in patients with COPD and type II respiratory failure: a meta-analysis and systematic review

Table 1 The characteristics of included RCTs

RCT	Country	Sample size		Intervention		Outcomes
RCT	Country	Experimental group	Control group	Experimental group	Control group	Outcomes
Ping 2018	China	47	46	HFNC	NIV	Incidence of tracheal intubation, mortality, incidence of nasal facial skin breakdown
Wang 2019	China	32	31	HFNC	NIV	Incidence of tracheal intubation, length of hospital stay
Jing 2018	China	38	37	HFNC	NIV	PaCO₂, PaO_2, Incidence of tracheal intubation, length of hospital stay
Jiang 2019	China	50	50	HFNC	NIV	PaCO₂, PaO_2, Incidence of tracheal intubation, length of hospital stay, mortality
Guo 2018	China	34	54	HFNC	NIV	PaCO₂, PaO_2, Incidence of tracheal intubation, length of hospital stay
Chen 2020	China	48	48	HFNC	NIV	PaCO₂, PaO₂, pH, Incidence of tracheal intubation mortality

Arterial blood oxygen partial pressure (PaO₂), carbon dioxide partial pressure (PaCO₂)

ISSN: 2047-783X