Differential hippocampal protein expression between normal mice and mice with the perioperative neurocognitive disorder: a proteomic analysis

Table 1 Details of differentially expressed proteins

Fold-change (1d postoperation, PND vs Control)	Fold-change (3d postoperation, PND vs Control)	Fold-change (7d postoperation, PND vs Control)	Protein function
4.04	5.29	6.93	Cellular potassium ion homeostasis
3.47	2.63	3.11	Heme binding
2.38	3.14	3.73	Positive regulation of MAP kinase activity Negative regulation of protein catabolic process
1.99	2.24	2.83	Mitochondrial outer membrane
2.36	2.73	2.40	Positive regulation of apoptotic process
2.59	2.29	2.01	Structural constituent of ribosome
2.23	1.76	1.89	Cytoplasm
2.01	2.22	1.99	SNARE binding
1.79	2.01	2.08	Pyruvate metabolism
1.87	1.54	1.49	Structural constituent of ribosome
1.98	1.88	1.44	1-Phosphatidylinositol binding
1.36	1.76	1.68	Biological process
0.66	0.70	0.74	Proteasome-mediated ubiquitin-dependent protein catabolic process
0.77	0.73	0.68	U1 snRNP binding
0.72	0.68	0.67	Structural constituent of ribosome
0.63	0.68	0.79	Protein binding
0.59	0.80	0.73	Negative regulation of dopamine metabolic process
0.61	0.61	0.43	Structural constituent of ribosome
0.54	0.52	0.27	Nucleus
0.54	0.52	0.27	Nucleus
0.57	0.58	0.66	Biological process

The commonly differential expression proteins at 1d, 3d, 7d postoperation (fold-change > 1.20 or fold-change < 0.83) were screened out. Fold-change > 1.20 means upregulation, and < 0.05 means downregulation (P < 0.05)

ISSN: 2047-783X