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Table 2 Comparison of NADRI with micro-ADRI and macro-ADRI in clinical and laboratory characteristics

From: Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency

Items

MacIsaac 2004 [5]

Rigalleau 2007 [18]

An 2009 [57]

Thomas 2009 [23]

Ekinci 2013 [58]

Vistisen 2019 [20]

Type 1

Type 2

N

43/38/28

15/36/38

44/50/57

506/295/119

8/6/17

427/264/244

942/664/378

Age (years)

73 ± 1/72 ± 2/67 ± 2*

68 ± 9 /65 ± 11/62 ± 13

59 ± 11 /57 ± 8/61 ± 9

73 ± 1/74 ± 1/71 ± 1

67 ± 2.0/69 ± 2.8/63 ± 2.0

65.0 ± 12.5/59.5 ± 13.4*/48.9 ± 13.2*

70.5 ± 8.5/69.5 ± 9.3*/66.1 ± 10.5*

Female (%)

56/45/18*

66/52/29*

77/66*/42*

64/50/43

62.5/16.7/17.7

62.8/46.2/36.1

52.3/36.0/29.3

BMI (kg/m2)

30.8 ± 1.0/29.3 ± 0.7/31.6 ± 1.4

27.0 ± 4.5/27.1 ± 4.5/26.7 ± 4.3

25.2 ± 2.6/23.9 ± 3.0/24.1 ± 2.8

–

34 ± 1.6/33 ± 2.7/31 ± 1.7

25.4 ± 4.6/25.1 ± 3.8/25.4 ± 4.2

30.4 ± 5.6/30.5 ± 5.7/30.7 ± 5.7

Smoking (%)

38/53/62

20/41/63*

18/18/19

5/8*/13*

0/50*/11.8

37.8/46.7/59.6

34.6/39.5/48.6

HTN (%)

-

–

36/52*/89*

–

–

–

–

SBP (mmHg)

138 ± 3/147 ± 3/147 ± 3

143 ± 16/145 ± 19/149 ± 19

–

135 ± 1/134 ± 1/137 ± 2

–

137.8 ± 20.0/138.6 ± 22.5*/144.6 ± 20.3*

136.8 ± 21.0/141.7 ± 21.5*/151.6 ± 23.7*

DBP (mmHg)

75 ± 2/78 ± 1/77 ± 1

79 ± 8/79 ± 9/83 ± 10

–

75 ± 1/75 ± 1/76 ± 1

–

72.8 ± 10.3/74.0 ± 11.3*/80.3 ± 11.4*

73.8 ± 11.2/75.7 ± 11.7*/79.2 ± 12.6*

HbA1c (%)

7.3 ± 0.3/7.9 ± 0.2/7.9 ± 0.3

9.0 ± 1.3/8.6 ± 1.3/8.5 ± 2.0

7.0 ± 1.1/7.9 ± 1.2*/7.2 ± 1.2

7.0 ± 0.1/7.3 ± 0.1*/7.5 ± 0.2*

6.8 ± 0.2/8.0 ± 0.5/7.3 ± 0.4

8.5 ± 1.3/8.8 ± 1.4*/9.2 ± 1.5*

8.1 ± 1.6/8.3 ± 1.7*/8.6 ± 1.7*

DD (years)

14 ± 1/16 ± 1/15 ± 2

14 ± 5/19 ± 12/19 ± 10

5.5 ± 2.3/9.3 ± 3.6*/19.5 ± 5.8*

9 ± 1/11 ± 1/12 ± 1

12 ± 2.4/12 ± 3.5/18 ± 2.1

32.2(22.6, 42.8)/34.6(24.4, 42.6)/29.2(22.6, 37)

12.8(7.6, 18.9)/13.6(7.8, 19.7)/14.5(8.7, 19.6)

TG (mmol/L)

(1.9 X/ ÷ 1.1)/ (1.8 X/ ÷ 1.1)/ (2.0 X/ ÷ 1.1)

2.16 ± 2.10/1.76 ± 0.10/2.21 ± 1.39

1.67 ± 0.94/1.7 6 ± 0.90/1.75 ± 1.01

1.9 ± 0.1/2.0 ± 0.1/2.2 ± 0.1

2.6 ± 0.4/1.8 ± 0.3/2.5 ± 0.4

1.1(0.8, 1.6)/1.2(0.9, 1.8)*/1.5(1.0, 2.2)*

1.8(1.3, 2.7)/2.0(1.4, 3.0)*/2.2(1.6, 3.2)*

TC (mg/dL)

4.4 ± 0.2/4.5 ± 0.2/4.3 ± 0.2

6.13 ± 1.73/5.25 ± 0.98/5.59 ± 1.45

4.42 ± 1.03/4.37 ± 0.91/4.60 ± 0.98

-

4.4 ± 0.2/4.1 ± 0.4/4.7 ± 0.3

5.1 ± 1.1/4.9 ± 1.1/5.5 ± 1.3

4.6 ± 1.2/4.6 ± 1.2/5.1 ± 1.5

HDL-C (mg/dL)

1.15 ± 0.05/1.19 ± 0.06/0.97 ± 0.05

1.66 ± 0.72/1.45 ± 0.49/1.27 ± 0.3*

1.19 ± 0.31/1.16 ± 0.28/1.14 ± 0.26

1.2 ± 0.1/1.3 ± 0.1/1.4 ± 0.1

-

1.8 ± 0.6/1.7 ± 0.6*/1.6 ± 0.6*

1.3 ± 0.4/1.2 ± 0 .4*/1.2 ± 0.4*

LDL-C (mg/dL)

2.6 ± 0.1/2.8 ± 0.1/2.5 ± 0.2

3.26 ± 1.19/2.95 ± 0.83/3.23 ± 1.22

2.46 ± 0.83/2.38 ± 0.85/2.64 ± 0.67

2.4 ± 0.1/2.3 ± 0.1/2.2 ± 0.1

-

2.7 ± 0.9/2.5 ± 0.9/3.1 ± 1.0

2.4 ± 1.0/2.4 ± 1.0/2.8 ± 1.3

DR (%)

26/50/41

26/61*/71*

15/56*/81*

10 ± 1/17 ± 2*/25 ± 4*

50/50/76.5

80/91/96.1

53.6/65.1/74.8

DN (%)

21/27/18

–

–

–

–

–

–

CVD (%)

–

13/31/46

18/20/32

7 ± 1/14 ± 2*/8 ± 2

–

–

–

  1. Data are presented as percentages or medians (interquartile range) or mean ± SEM or mean ± SD or geometric mean X/ ÷ tolerance factor.* means P < 0.05 versus the normoalbuminuric diabetes with renal insufficiency. NADRI: normoalbuminuric diabetes with renal insufficiency; micro-ADRI: micro-albuminuric diabetes with renal insufficiency; macro-ADRI: macro-albuminuric diabetes with renal insufficiency; N: number; BMI: body mass index; HTN: hypertension; SBP: systolic blood pressure; DBP: diastolic blood pressure; HbA1c: glycated hemoglobin; DD: diabetes duration; TG: triglycerides; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; DR: diabetic retinopathy; DN: diabetic neuropathy; CVD: cardiovascular disease