Fig. 2

Pathological effects of STING on lung injury induced by IR. A Representative photomicrographs of H&E- and Masson trichrome-stained sections. Scale bar = 50 μm. Arrows indicate lung injury and lung collagen, respectively. B Lung injury score and C the percentage of lung collagen content caused by the indicated stimuli 3 h after IR. D Total lung water content (TLW); E content of bronchoalveolar lavage fluid (BALF) protein; F diamine oxidase (DAO) content in serum; and G IL-1β levels in the serum caused by the indicated stimuli 3 h after IR. Data are presented as the mean ± SD (n = 6). Sham, IR, C-176, and vehicle are described above. ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05