Correlation between dynamic changes in free triiodothyronine levels and 90-day prognosis in patients with HBV-related acute-on-chronic liver failure

Table 1 HBV–ACLF patient demographic information at admission

	Survival group (77 cases)	Non-survival group (45 cases)	P value
Clinical characteristics
Age (year)	44.65 ± 10.58	48.85 ± 10.13	0.057
Gender(m/f)	64/13	35/10	< 0.001
Chronic hepatitis B/cirrhosis	32/45	14/31	< 0.001
HBV reactivation	30	15
Intra-abdominal infection	22	9
Alcohol drinking	10	6
Gastrointestinal bleeding	6	6
Respiratory infection	6	4
Drug	5	3
Laboratory test
ALT (U/L)	439.11 ± 239.23	331.48 ± 204.39	0.328
AST (U/L)	348.91 ± 216.14	302.59 ± 194.49	0.642
TBil (µmol/L)	365.14 ± 156.89	432.21 ± 151.34	0.040
PT–INR	2.61 ± 0.86	3.70 ± 0.86	< 0.001
Ln(HBV DNA)	3.82 ± 2.09	3.90 ± 1.52	0.753
Cr (µmol/L)	65.13 ± 28.85	115.03 ± 53.66	0.004
ALB (g/L)	30.44 ± 4.03	29.34 ± 3.54	0.173
Na (mmol/L)	136.30 ± 3.37	133.82 ± 5.73	0.007
WBC (× 10⁹/L)	7.69 ± 3.62	8.63 ± 4.07	0.235
FT3	2.66 ± 0.65	2.43 ± 0.48	0.087
Prognostic score
CTP	11.54 ± 1.34	12.43 ± 1.44	0.002
MELD	28.10 ± 4.54	32.83 ± 4.68	< 0.001
MELD–Na	28.74 ± 4.32	33.49 ± 4.34	< 0.001
CLIF–SOFA	8.43 ± 1.72	10.46 ± 2.36	< 0.001
CLIF–OF	9.68 ± 1.54	11.14 ± 1.46	< 0.001
AARC	9.33 ± 1.78	10.80 ± 1.23	< 0.001

ALT alanine aminotransferase, AST aspartate aminotransferase, TBil total bilirubin, INR international normalized ratio, Cr Creatinine, ALB albumin, BUN blood urea nitrogen, WBC white blood count, FT3 free triiodothyronine, thyroid‐stimulating hormone, CTP Child–Turcotte–Pugh score, MELD model for end-stage liver disease score, MELD–Na MELD–sodium score, CLIF‐SOFA chronic liver failure–sequential organ failure assessment, CLIF–C OF CLIF–consortium organ failure score, AARC APASL ACLF research consortium
P < 0.05 was considered to be statistically significant

ISSN: 2047-783X