Table 2 Cancer-promoting mechanism of TXNDC5

Regulate cell cycle

GC

–

Up

–

Increase percentage of cells in G2/M phase

[25]

GC

–

Silence

–

Increase percentage of cells in 0/G1 phase

[25]

CRPC

–

Up

–

Cause cell cycle disorders between G2/M and S phases

[29]

Protect cells from oxidative stress

CRC

Hif-1α

Up

Inhibit ROS/ER stress

Promote the reproduction and survival of cells under hypoxia

[28]

CRPC

Hif-1α& miR-200b

Up

Interact with AR and enhance its transcriptional activity

promote the progression of CRPC

[29]

Signalling pathway

CC

–

Inhibition

Increase expression of SERPINF1 and TRAF1

Inhibit angioplasty, cell proliferation and migration

[26]

LC

–

Up

Combine with Srx

Promote cell proliferation and metastasis

[30, 31]