The role and mechanism of TXNDC5 in diseases

Table 3 Expression regulation mechanism of TXNDC5 in cancer cells

Molecule	Cancers	Pathway	TXNDC5 expression	Effect	Ref
Circ_0000517	HCC	miR-1296-5p	Up	Promote proliferation and colony formation; inhibit apoptosis	[35]
HERG1	ESCC	PI3K/AKT	Up	Promote cancer progression	[37]
NR4A1	PC/RCC/RMS	–	Up	Inhibit apoptosis; anti-ROS/ER stress	[38,39,40]
Cetuximab	LSCC	Suppress TXNDC5 gene promoter	Down	Increase ERS stress-related apoptosis	[43]

HERG1 human ether a-go-go-related gene 1, NR4A1 nuclear receptor 4A1, HCC hepatocellular carcinoma, ESCC Esophageal squamous cell carcinoma, PC pancreatic cancer, RCC renal cell carcinoma, RMS rhabdomyosarcoma, LSCC laryngeal squamous cell carcinoma

ISSN: 2047-783X