Table 2 Clinicopathological findings of IgG subclass deposit on GBM
None (n = 14) | Isotype (n = 61) | Mixed (n = 33) | P Value | |
|---|---|---|---|---|
Male (%) | 85.7 | 67.2 | 72.7 | 0.365 |
Age (year) | 56.5 ± 9.0 | 53.3 ± 8.8 | 53.5 ± 10.4 | 0.497 |
Duration of diabetes (mo) | 90.0 (36.0, 129.0) | 96.0 (36.0, 120.0) | 120.0 (45.0, 141.1) | 0.857 |
Duration of nephropathy (mo) | 1.0 (1.0, 24.0) | 2.0 (1.0, 12.0) | 5.5 (1.0, 8.0) | 0.465 |
Proteinuria(g/24 h) | 3.3 (1.1, 4.8) | 3.2 (1.3, 6.0) | 6.5 (1.7, 9.1) | 0.047 |
Albumin (g/L) | 31.4 ± 5.4 | 32.1 ± 7.4 | 29.8 ± 7.2 | 0.337 |
Scr(μmol/L) | 145.0 (71.9, 182.0) | 117.0 (72.8, 154.5) | 103.0 (82.9, 132.5) | 0.346 |
eGFR (ml/min/1.73m2) | 46.9 (29.0, 109.1) | 64.0 (36.7, 112.0) | 65.0 (52.0, 96.1) | 0.838 |
DN stage I [n(%)] | 2 (14.3) | 5 (8.2) | 1 (3.0) | 0.272 |
DN stage II [n(%)] | 4 (28.6) | 14 (23.0) | 8 (24.2) | 0.857 |
DN stage III [n(%)] | 7 (50.0) | 40 (65.6) | 23 (69.7) | 0.429 |
DN stage IV [n(%)] | 1 (7.1) | 2 (3.3) | 1 (3) | 0.598 |
IgG intensity | 1.0 (1.0, 1.0) | 1.0 (1.0, 1.0) | 1.0 (1.0, 1.5) | 0.384 |
C3 intensity | 0.0 (0.0, 1.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.5) | 0.467 |
GS (%) | 14.9 (9.9, 36.1) | 23.2 (10.0, 40.0) | 16.7 (5.1, 25.6) | 0.360 |
CD34 + area (%) | 24.0 ± 7.8 | 23.2 ± 7.6 | 26.7 ± 9.0 | 0.134 |
GBM thickness (nm) | 711.8 ± 126.5 | 776.9 ± 183.3 | 713.2 ± 184.9 | 0.247 |
FPE | 3.0 (2.0, 3.0) | 3.0 (2.0, 3.0) | 3.0 (2.5, 3.0) | 0.707 |
IFTA score | 1.9 ± 0.8 | 2.1 ± 0.6 | 2.0 ± 0.7 | 0.816 |
KIM-1 + area (%) | 20.0 (15.0, 32.5) | 30.0 (15.0, 40.0) | 30.0 (16.3, 47.5) | 0.500 |
TBM thickness (nm) | 1225.8 ± 288.3 | 1215.1 ± 354.2 | 1234.2 ± 524.3 | 0.976 |
Inter-infla score | 2.0 (1.0, 2.5) | 2.0 (2.0, 2.0) | 2.0 (2.0, 2.0) | 0.850 |
Hyalinosis score | 1.8 ± 0.5 | 1.7 ± 0.5 | 1.8 ± 0.4 | 0.507 |
A-sclerosis score | 1.0 (0.3, 1.0) | 1.0 (0.0, 1.0) | 1.0 (0.0, 1.0) | 0.948 |