Fig. 4From: AMP-activated protein kinase α2 contributes to acute and chronic hyperuricemic nephropathy via renal urate deposition in a mouse modelAMPK α2 exacerbated profibrotic TGF-β/Smad3 signaling in a mouse model of chronic HN. a–e Western blot analysis of α-SMA, TGF-β1, p-Smad3 and total Smad3 expression in the kidneys. Each bar represents the mean ± SEM. Versus CON, **P < 0.01 and ***P < 0.001; versus WT, #P < 0.05 and ##P < 0.01Back to article page