Skip to main content

Table 3 Association between plasma lipoprotein a levels and cardiovascular diseases in Mendelian randomization analysis (six different methods corresponding to the results), heterogeneity as well as horizontal multiplicity test analysis

From: The relationship between lipoprotein(a) and risk of cardiovascular disease: a Mendelian randomization analysis

Outcome

MR methods

OR (95% CI)

P for association

P for heterogeneity test

P for MR-Egger intercept

AA

MR-Egger

1.010 (1.002–1.019)

0.038

0.623

0.220

IVW1

1.005 (1.001–1.010)

0.009

0.544

Weighted median

1.006 (1.000–1.011)

0.039

 

Maximum likelihood

1.006 (1.001–1.010)

0.009

 

PWM

1.006 (1.000–1.011)

0.042

 

IVW2

1.005 (1.001–1.010)

0.009

 

CHD

MR-Egger

0.999 (0.992–1.005)

0.723

0.753

0.271

IVW1

1.003 (1.001–1.004)

0.010

0.703

Weighted median

1.003 (1.001–1.006)

0.014

 

Maximum likelihood

1.003 (1.001–1.004)

0.010

 

PWM

1.003 (1.001–1.006)

0.011

 

IVW2

1.003 (1.001–1.004)

0.010

 

ISL

MR-Egger

1.003 (1.001–1.004)

3.56E-04

0.588

0.381

IVW1

1.003 (1.002–1.004)

9.50E-11

0.599

Weighted median

1.003 (1.002–1.004)

1.05E-07

 

Maximum likelihood

1.003 (1.002–1.004)

9.10E-11

 

PWM

1.003 (1.002–1.004)

2.28E-07

 

IVW2

1.003 (1.002–1.004)

9.50E-11

 

AF

MR-Egger

1.002 (1.000–1.005)

0.070

0.829

0.204

IVW1

1.001 (1.000–1.002)

0.097

0.756

Weighted median

1.001 (1.000–1.003)

0.089

 

Maximum likelihood

1.001 (1.000–1.002)

0.098

 

PWM

1.001 (1.000–1.002)

0.083

 

IVW2

1.001 (1.000–1.002)

0.097

 

HBP

MR-Egger

1.000 (0.998–1.002)

0.997

0.457

0.900

IVW1

1.000 (0.998–1.002)

0.927

0.532

Weighted median

1.000 (0.998–1.002)

0.892

 

Maximum likelihood

1.000 (0.998–1.002)

0.927

 

PWM

1.000 (0.998–1.002)

0.894

 

IVW2

1.000 (0.998–1.002)

0.927

 

HF

MR-Egger

1.000 (0.994–1.005)

0.883

0.060

0.909

IVW1

0.999 (0.997–1.002)

0.584

0.088

Weighted median

1.000 (0.997–1.003)

0.917

 

Maximum likelihood

0.999 (0.997–1.001)

0.489

 

PWM

1.000 (0.997–1.003)

0.921

 

IVW2

0.999 (0.997–1.001)

0.488

 

IS

MR-Egger

1.001 (1.000–1.002)

0.152

0.197

0.514

IVW1

1.001 (1.000–1.001)

0.156

0.223

Weighted median

1.001 (1.000–1.001)

0.069

 

Maximum likelihood

1.001 (1.000–1.001)

0.112

 

PWM

1.001 (1.000–1.001)

0.698

 

IVW2

1.001 (1.000–1.001)

0.112

 

LIS

MR-Egger

1.000 (1.000–1.001)

0.847

0.159

0.736

IVW1

1.000 (1.000–1.001)

0.524

0.205

Weighted median

1.000 (0.999–1.000)

0.331

 

Maximum likelihood

1.000 (0.999–1.000)

0.466

 

PWM

1.000 (0.999–1.000)

0.314

 

IVW2

1.000 (0.999–1.000)

0.466

 

ISS

MR-Egger

0.999 (0.998–1.001)

0.353

0.007

0.381

IVW1

0.999 (0.998–1.001)

0.430

0.009

Weighted median

0.999 (0.998–1.000)

0.071

 

Maximum likelihood

0.999 (0.999–1.000)

0.265

 

PWM

0.999 (0.998–1.000)

0.723

 

IVW2

0.999 (0.999–1.000)

0.265

 

PE

MR-Egger

1.000 (0.998–1.001)

0.826

0.240

0.204

IVW

1.000 (0.998–1.000)

0.210

0.192

Weighted median

1.000 (0.999–1.001)

0.835

 

Maximum likelihood

0.999 (0.998–1.000)

0.152

 

PWM

1.000 (0.999–1.001)

0.879

 

IVW2

0.999 (0.998–1.000)

0.152

 
  1. IVW1 random-effects inverse variance weighting, IVW2 fixed-effects model inverse variance weighting, PWM penalized weighted median, OR odds ratio, CI confidence interval, AA aortic aneurysm CHD coronary heart disease. ISL large artery atherosclerosis stroke, AF atrial fibrillation, HBP secondary hypertension, HF heart failure, IS ischemic stroke, LIS lacunar stroke, ISS small vessel stroke, PE pulmonary embolism
Back to article page

European Journal of Medical Research

ISSN: 2047-783X

Contact us