Biomarkers of interstitial lung disease associated with primary Sjögren's syndrome

Table 3 Factors discriminating pSS–moderate/advanced ILD from pSS–no/indeterminate ILD

Variable	Mild/moderate and severe ILD Disease (ILA score 2 + 3)
Variable	AUC	95% CI	p value
Age at diagnosis of pSS	0.706	0.582–0.830	0.003**
Disease duration	0.584	0.448–0.719	0.232
IgG	0.518	0.377–0.660	0.792
IgM	0.653	0.521–0.785	0.029*
IgA	0.589	0.453–0.725	0.203
C3	0.604	0.467–0.741	0.138
C4	0.590	0.453–0.726	0.201
CRP	0.713	0.590–0.836	0.002**
ANA positive	0.531	0.394–0.668	0.657
Anti-SSA/RO-60 positive	0.608	0.474–0.742	0.123
Anti-SSB/La positive	0.597	0.463–0.732	0.164
Anti-Ro-52 positive	0.540	0.404–0.677	0.565
eotaxin/CCL11	0.695	0.571–0.818	0.006**
KL-6	0.883	0.798–0.969	< 0.0001***
TGF-α	0.618	0.484–0.753	0.091
TNF-a	0.656	0.527–0.785	0.026*

AUC area under the curve
^*p < 0.05, **p < 0.01, ***p < 0.001 when the pSS moderate/advanced-ILD group (ILA score 2 + 3) was compared with the pSS no/indeterminate-ILD group (ILA score 0 + 1)
Bold values represent the statistic significances p < 0.05

ISSN: 2047-783X