Table 1 GO biological process and KEGG signal pathway significantly related to target genes

Biology Process

GO:0030334 ~ regulation of cell migration

2.26E−04

DLC1, PARD6B, IRS2, FLT1

GO:0040012 ~ regulation of locomotion

2.48E−04

DLC1, PDGFB, ENPP2, TAC1,

GO:0001501 ~ skeletal system development

4.90E−04

TUFT1, GNA11, HEXA, HOXD12

GO:0051270 ~ regulation of cell motion

6.45E−04

SORT1, PDGFRB, PBX1, IGFBP3

GO:0033043 ~ regulation of organelle organization

6.92E−04

DLC1, SHROOM2, CAPZA1, TAC1

GO:0007242 ~ intracellular signaling cascade

1.24E−03

RAB9A, ADCY7, PLEKHM1, GNA11

GO:0030029 ~ actin filament-based process

1.53E−03

CHEK1, ARF5, TP53TG5, P2RY1

GO:0007517 ~ muscle organ development

2.22E−03

NMUR1, RHOF, CHUK, RAP2B

GO:0030036 ~ actin cytoskeleton organization

2.66E−03

GDI1, FLT1, MCF2, IGF1,

GO:0045184 ~ establishment of protein localization

3.89E−03

RAB9A, APOBEC1, AP1G1, SLC15A2

KEGG pathway

hsa04630:Jak–STAT signaling pathway

9.44E−03

CSF3, PTPN6, CTF1, SOCS1

hsa01040:Biosynthesis of unsaturated fatty acids

1.49E−02

BAAT, ELOVL5, HSD17B12, ELOVL2,

hsa00480:Glutathione metabolism

1.95E−02

GGT5, GSTA4, G6PD, RRM2

hsa04960:Aldosterone-regulated sodium reabsorption

2.03E−02

MAPK1, IRS2, MAPK3, IGF1,

hsa00670:One carbon pool by folate

2.07E−02

MTHFD2, MTHFR, SHMT2, MTR

hsa04350:TGF-beta signaling pathway

3.51E−02

INHBB, MAPK1, SP1, ROCK2

hsa00510:N-Glycan biosynthesis

3.60E−02

MAN2A1, B4GALT3, GANAB, MAN1B1

hsa04514:Cell adhesion molecules (CAMs)

3.65E−02

CLDN8, CLDN7, CLDN17, MPZL1,

hsa04540:Gap junction

4.05E−02

MAPK1, PLCB4, GNAI3, ADCY7

hsa04722:Neurotrophin signaling pathway

4.44E−02

PDK1, IRS2, CAMK2G, IRS1