Fig. 3

5-HT2B was required for normal social interaction and repetitive behavior in Drosophila. A, C Representative data show the distance to the closest neighbor of the five Ubi-Gal4-driven 5-HT receptor knockdown and Gal4 control flies in males (A) or females (C). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. B, D Cumulative probability distributions of males (B) and females (D) over 5-HT receptor knockdown and control flies. E, F Number of grooming episodes recorded by grooming assay of flies of all 5 receptors knocked down in both sexes (E for males, and F for females) in the 5-min observation period. Error bars are shown as the mean ± SEM (E) and (F)