Fig. 2

Results of gene set variation analysis using asthma- and COPD- specific gene signatures. The GSVA enrichment scores were calculated across 70 whole-sputum gene expression profiles. ACO clusters 1 and 2 were identified from k-means clustering using the enrichments scores obtained from the GSVA with asthma- and COPD-specific gene signatures in the elderly with ACO. Dots represent the individual enrichment scores, and box and whisker plots show the median and interquartile range. Gene lists of asthma- and COPD-specific gene signatures are provided in the online supplement. GSVA gene set variation analysis, ACO asthma-COPD overlap, COPD chronic obstructive pulmonary disease, NS not significant