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Table 2 Results of computerized glycemic variability index

From: Regimen comprising GLP-1 receptor agonist and basal insulin can decrease the effect of food on glycemic variability compared to a pre-mixed insulin regimen

 

Pre-mix insulin usage (N = 16)

GLP-1 agonist added on basal insulin usage (n = 16)

p

All day period (0:00–24:00)

 SD

43.9 [34.4, 60.6]

36.0 [27.7, 47.5]

0.017a

 CV

0.24 [0.21, 0.29]

0.20 [0.15, 0.26]

0.046a

 MAGE

114.2 [91.4, 151.4]

78.7 [66.8, 124.8]

0.006a

 AUCt

50869.2 [44430.2, 66563.7]

53484.3 [41642.7, 59404.7]

0.918

 AUC180

31850.4 [15978.1, 55968.9]

34434.3 [12336.0, 46503.3]

0.535

 AUCn

18672.2 [9534.4, 28527.5]

19419.5 [13836.7, 28965.2]

0.408

 AUC70

0.0 [0.0, 175.0]

0.0 [0.0, 0.0]

0.674

 LBGI

0.07 [0.00, 0.41]

0.00 [0.00, 0.18]

0.463

 HBGI

9.68 [5.41, 20.28]

9.46 [4.14, 14.48]

0.535

 M-value

23.47 [13.12, 45.15]

18.45 [10.49, 27.86]

0.088

 CONGA1

28.07 [23.33, 39.29]

23.25 [19.93, 34.58]

0.079

 CONGA2

42.80 [35.88, 56.29]

36.45 [31.46, 54.49]

0.049a

 CONGA4

56.94 [45.81, 70.33]

50.49 [38.80, 62.95]

0.020a

 TIR

39.0 [24.1, 71.7]

52.6 [31.4, 77.6]

0.305

 Duration above upper limit (%)

61.0 [27.0, 76.0]

47.4 [19.9, 68.6]

0.352

 Duration within limits (%)

39.0 [24.1, 71.7]

52.6 [31.4, 77.6]

0.453

 Duration below lower limit (%)

0.0 [0.0, 0.6]

0.0 [0.0, 0.0]

0.624

Nocturnal period (00:00–06:00)

 SD

14.8 [9.3, 20.2]

11.5 [9.39, 19.9]

0.605

 CV

0.09 [0.08, 0.13]

0.07 [0.06, 0.13]

0.796

 MAGE

34.9 [23.1, 50.4]

32.9 [25.1, 60.0]

0.642

 AUCt

11771.3 [8691.5, 14551.0]

11015.0 [8383.6, 12973.3]

0.569

 AUC180

3822.2 [260.1, 12524.9]

2262.3 [13.6, 6654.3]

0.363

 AUCn

6176.7 [2794.0, 8419.7]

7392.8 [5662.3, 8730.4]

0.278

 AUC70

0.0 [0.0, 0.0]

0.0 [0.0, 0.0]

0.715

 LBGI

0.09 [0.00, 0.59]

0.00 [0.00, 0.51]

0.552

 HBGI

6.24 [1.32, 14.17]

4.31 [0.86, 8.44]

0.379

 M-value

8.96 [5.01, 22.66]

7.71 [3.32, 15.82]

0.408

 CONGA1

13.20 [9.52, 16.57]

10.61 [8.53, 13.21]

0.438

 CONGA2

14.12 [11.61, 19.84]

12.58 [10.17, 16.80]

0.234

 CONGA4

11.64 [9.15, 13.36]

9.87 [8.08, 14.26]

0.642

  1. Each glycemic variability index is presented as the median [Q1, Q3]. Continuous variants were analyzed by Wilconxon singed-rank test
  2. SD standard deviation; CV coefficient of variation; MAGE mean amplitude of glycemic excursions; AUC area under curve; LBGI low blood glucose index; HBGI high blood glucose index; M-value weighted average of glucose value; CONGA continuous overlapping net glycemic action; TIR time in range
  3. adenotes p value < 0.05