Regimen comprising GLP-1 receptor agonist and basal insulin can decrease the effect of food on glycemic variability compared to a pre-mixed insulin regimen

Lin, Yi-Hsuan; Lin, Chia-Hung; Huang, Yu-Yao; Chen, Hsin-Yun; Tai, An-Shun; Fu, Shih-Chen; Hsieh, Sheng-Hwu; Sun, Jui-Hung; Chen, Szu-Tah; Lin, Sheng-Hsuan

doi:10.1186/s40001-022-00892-9

Table 3 Impact of nutrient components on MAGE, SD and CV

From: Regimen comprising GLP-1 receptor agonist and basal insulin can decrease the effect of food on glycemic variability compared to a pre-mixed insulin regimen

Parameter	MAGE (mg/dl)
Parameter	Total person times (n = 32)			Pre-mix insulin regimen (n = 16)			GLP-1 RA on basal insulin regimen (n = 16)
Variable	β	95% CI of β	P	β	95% CI of β	p	β	95% CI of β	p
CHO (%)	1.141	(− 0.481,2.763)	0.168	2.699	(0.067,5.332)	0.045^a	0.918	(− 1.567, 3.404)	0.441
Pro (%)	− 6.494	(− 12.124, -0.865)	0.023^a	− 3.462	(− 14.797,7.873)	0.523	− 2.267	(− 11.893, 7.358)	0.621
Fat (%)	− 1.092	(− 3.013, 0.827)	0.264	− 3.487	(− 6.529, -0.446)	0.028^a	− 1.076	(− 4.028, 1.876)	0.448
CHO (gram/kg)	14.80	(− 11.941,41.546)	0.278	16.77	(− 28.008,61.556)	0.435	11.49	(− 30.454,53.428)	0.566
Pro (gram/kg)	− 51.39	(− 123.139,20.357)	0.160	− 47.77	(− 159.053,63.518)	0.373	− 18.49	(− 123.15,86.172)	0.711
Fat (gram/kg)	− 26.80	(− 82.136,28.523)	0.342	− 67.82	(− 146.583,10.939)	0.086	− 23.13	(− 107.945, 61.689)	0.568
Parameter	SD (mg/dl)
CHO (%)	0.440	(− 0.165,1.045)	0.154	1.324	(0.409,2.239)	0.008^a	0.266	(− 0.704,1.235)	0.566
PRO (%)	− 2.768	(− 4.786,-0.750)	0.007v	− 2.854	(− 7.023,1.315)	0.164	− 1.155	(− 4.849,2.539)	0.513
Fat (%)	− 0.369	(− 1.085,0.347)	0.312	− 1.595	(− 2.677–0.513)	0.007^a	− 0.263	(− 1.419,0.892)	0.632
CHO (gram/kg)	4.874	(− 5.153,14.901)	0.340	8.475	(− 8.677,25.627)	0.307	4.403	(− 11.806,20.612)	0.570
PRO (gram/kg)	− 17.00	(− 44.015,10.019)	0.217	− 21.63	(− 64.482,21.213)	0.297	− 3.635	(− 44.228,36.959)	0.851
Fat (gram/kg)	− 5.428	(− 26.362,15.469)	0.610	− 25.17	(− 56.163,5.821)	0.103	− 4.297	(− 37.377,28.782)	0.785
Parameter	CV (%)
CHO (%)	0.003	(0.0007,0.006)	0.011^a	0.004	(0,0.009)	0.061	0.003	(− 0.001,0.006)	0.120
PRO (%)	− 0.013	(− 0.023,-0.003)	0.013^a	− 0.021	(− 0.036,-0.006)	0.009^a	− 0.004	(− 0.019,0.011)	0.566
Fat (%)	− 0.004	(− 0.007,-0.0002)	0.032^a	− 0.004	(− 0.01,0.002)	0.158	− 0.004	(− 0.008,0.001)	0.095
CHO (gram/kg)	0.006	(− 0.041,0.052)	0.806	0.001	(− 0.075,0.078)	0.971	− 0.002	(− 0.593,0.553)	0.941
PRO (gram/kg)	− 0.134	(− 0.243,-0.025)	0.016^a	− 0.187	(− 0.346,-0.029)	0.023^a	− 0.1	(− 0.254,0.054)	0.186
Fat (gram/kg)	− 0.097	(− 0.182,-0.012)	0.025^a	− 0.113	(− 0.245,0.018)	0.085	− 0.105	(− 0.225,0.014)	0.080

Linear mixed model analysis with β as standardized coefficient
MAGE mean amplitude of glycemic excursions; SD standard deviation; CV coefficient of variation; CHO carbohydrate; PRO protein
^adenotes p value < 0.05

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