The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study

Table 2 The effect estimates, test of heterogeneity and test of pleiotropy of white cell counts on HCC (discovery)

Exposure	NSNP	MR methodology	Effect Estimates HCC			P value	Test of heterogeneity		Test of pleiotropy
Exposure	NSNP	MR methodology	OR	95% LCI	95% UCI	P value	Cochrane Q test	Pheterogeneity	MR-Egger intercept	Ppleiotropy
Eosinophil counts	163	IVW	0.560	0.307	1.022	0.059	149.961	0.742
		MR Egger	0.559	0.136	2.295	0.421	149.961	0.723	< 0.001	0.997
		Weighted median	0.492	0.191	1.268	0.142
Basophil counts	73	IVW	1.039	0.384	2.811	0.939	76.405	0.339
		MR Egger	1.098	0.126	9.598	0.933	76.401	0.309	− 0.002	0.955
		Weighted median	1.055	0.224	4.976	0.946
Neutrophil counts	135	IVW	0.737	0.368	1.476	0.389	165.929	0.032
		MR Egger	1.589	0.285	8.875	0.406	164.740	0.032	− 0.031	0.329
		Weighted median	1.144	0.328	3.989	0.832
Lymphocyte counts	145	IVW	0.636	0.320	1.266	0.198	154.957	0.251
		MR Egger	0.301	0.043	2.101	0.228	154.245	0.246	0.029	0.418
		Weighted median	0.666	0.212	2.099	0.488
Monocyte counts	173	IVW	1.213	0.717	2.051	0.472	167.025	0.593
		MR Egger	0.844	0.315	2.260	0.736	166.300	0.587	0.019	0.395
		Weighted median	1.170	0.512	2.673	0.709
Sum eosinophil basophil counts	162	IVW	0.691	0.375	1.273	0.236	167.036	0.574
		MR Egger	0.765	0.186	3.145	0.711	157.012	0.552	− 0.004	0.877
		Weighted median	0.549	0.207	1.455	0.228
Sum neutrophil eosinophil counts	134	IVW	0.806	0.403	1.614	0.544	160.745	0.051
		MR Egger	1.300	0.233	7.246	0.765	160.297	0.047	− 0.019	0.544
		Weighted median	1.155	0.331	4.030	0.821
Sum basophil neutrophil counts	157	IVW	0.400	0.233	0.684	< 0.001	174.065	0.143
		MR Egger	0.342	0.113	1.034	0.059	174.750	0.132	0.008	0.749
		Weighted median	0.450	0.188	1.078	0.445

NSNP is the number of single nucleotide polymorphism; Odds ratio (OR) is per 1-SD increase; 95% LCI is the lower limit of 95% confidence interval; 95% UCI is the upper limit of 95% confidence interval; p value is the p-value of OR; Pheterogeneity is the p-value of Cochrane’s Q value in heterogeneity test; Ppleiotropy is the p-value of MR-Egger intercept. IVW is IVW with a fixed-effects model

ISSN: 2047-783X