The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study

Table 3 The effect estimates, test of heterogeneity and test of pleiotropy of white cell counts on HCC (validation)

Exposure	NSNP	MR methodology	Effect Estimates HCC				Test of Heterogeneity		Test of Pleiotropy
Exposure	NSNP	MR methodology	OR	95% LCI	95% UCI	P value	Cochrane Q test	Pheterogeneity	MR-Egger intercept	Ppleiotropy
Eosinophil counts	163	IVW	0.568	0.338	0.954	0.033	185.025	0.104
		MR Egger	0.196	0.054	0.715	0.015	181.455	0.129	0.047	0.077
		Weighted median	0.454	0.202	1.022	0.057
Basophil counts	73	IVW	0.509	0.215	1.202	0.123	74.866	0.385
		MR Egger	0.151	0.024	0.938	0.046	72.617	0.424	0.047	0.143
		Weighted median	0.677	0.181	2.537	0.563
Neutrophil counts	135	IVW	0.817	0.449	1.488	0.509	137.905	0.391
		MR Egger	0.561	0.144	2.186	0.406	137.525	0.376	0.015	0.545
		Weighted median	0.527	0.183	1.522	0.237
Lymphocyte counts	145	IVW	0.944	0.521	1.711	0.851	142.808	0.512
		MR Egger	1.155	0.230	5.809	0.861	142.739	0.490	− 0.008	0.793
		Weighted median	1.075	0.428	2.704	0.878
Monocyte counts	173	IVW	0.671	0.426	1.056	0.085	174.197	0.439
		MR Egger	0.418	0.178	0.982	0.047	172.535	0.453	0.025	0.201
		Weighted median	0.517	0.238	1.121	0.095
Sum eosinophil basophil counts	162	IVW	0.596	0.352	1.009	0.054	186.616	0.082
		MR Egger	0.156	0.042	0.571	0.006	180.917	0.123	0.002	0.936
		Weighted median	0.380	0.163	0.885	0.025
Sum neutrophil eosinophil counts	134	IVW	0.693	0.381	1.262	0.230	143.089	0.260
		MR Egger	0.658	0.162	2.683	0.561	143.082	0.241	0.002	0.936
		Weighted median	0.523	0.183	1.494	0.226
Sum basophil neutrophil counts	157	IVW	0.573	0.361	0.909	0.018	147.495	0.632
		MR Egger	0.284	0.117	0.690	0.006	146.179	0.682	0.037	0.071
		Weighted median	0.331	0.158	0.695	0.004

NSNP is the number of single nucleotide polymorphism; Odds ratio (OR) is per 1-SD increase; 95% LCI is the lower limit of 95% confidence interval; 95% UCI is the upper limit of 95% confidence interval; P value is the P-value of OR; Pheterogeneity is the P-value of Cochrane’s Q value in heterogeneity test; Ppleiotropy is the P-value of MR-Egger intercept. IVW is IVW with a fixed-effects model

ISSN: 2047-783X