Doxycycline vs. macrolides in combination with a β-lactam antibiotic for the treatment of community-acquired pneumonia in inpatients

Table 2 Patients outcomes

Outcome	BL-D (n = 57)	BL-M (n = 140)	P value
Time to clinical stability (days)	4 [3–6]	4 [2–7]	0.822
Clinical cure	54 (94.7)	128 (91.4)	0.427
LOS (days)	7 [5–9.5]	7 [5–10]	0.623
ICU admission	1 (1.8)	3 (2.1)	0.861
In-hospital mortality	1 (1.8)	2 (1.4)	0.866
30 day readmission	9 (15.8)	13 (9.3)	0.189
Resolved leukocytosis	9 (47.4)	34 (51.5)	0.750
Resolved fever	24 (100)	32 (94.1)	0.227
EOT SpO₂, %	99.5 [99–100]	99 [98–100]	0.173
Elevation of liver enzymes	3 (5.3)	30 (21.4)	0.006

Results are presented as n (%) or median [IQR]
BL-D β-Lactam + doxycycline, BL-M β-Lactam + macrolide, EOT end of therapy, ICU intensive care unit, LOS length of stay, SpO₂ oxygen saturation

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