Association between heme oxygenase one and sepsis development in patients with moderate-to-critical COVID-19: a single-center, retrospective observational study

Table 5 Multiple linear regression models of 48-h SOFA score factors (n = 156)

Variables	\(\beta\)	SE	\(\beta\) 95% CI		p-value
Variables	\(\beta\)	SE	Lower	Upper	p-value
Initial CURB-65	0.582	0.119	0.347	0.817	< 0.001**
d-dimer (ng/mL)	0.323 × 10^–3	0.044 × 10^–3	0.236 × 10^–3	0.411 × 10^–3	< 0.001**
aPTT (s)	0.084	0.022	0.039	0.128	< 0.001**
BMI (m/kg²)	0.093	0.024	0.046	0.139	< 0.001**
Creatinine (mg/dL)	0.282	0.073	0.137	0.426	< 0.001**
SpO₂ (%)	-0.051	0.017	-0.085	-0.017	0.004*
CRP (mg/dL)	0.062	0.019	0.023	0.100	0.002*
HO-1 (ng/mL)	0.016	0.003	0.010	0.022	< 0.001**

Multiple linear regression model: stepwise method selection
aPTT activated partial thromboplastin time, BMI body mass index, CI confidence interval, CRP C-reactive protein, CURB-65 confusion; blood urea nitrogen, respiratory rate, blood pressure, in patients aged > 65 years, HO-1 heme oxygenase-1, OR odds ratio, SE standard error, SOFA Sequential Organ Failure Assessment, SpO₂ saturation of pulse oximeter
*p < 0.05; **p < 0.001. Dependent variable: SOFA score

ISSN: 2047-783X