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Table 6 Cox regression model after adjusting for other confounding factors

From: Association between heme oxygenase one and sepsis development in patients with moderate-to-critical COVID-19: a single-center, retrospective observational study

 

Bivariate

Multivariate

HR (95% CI)

p-value

HR (95% CI)

p-value

SARS-CoV-2 CtV

0.971 (0.909–1.039)

NS

  

Sex

1.282 (0.575–2.858)

NS

  

Body mass index

1.013 (0.947–1.084)

NS

  

CCI

1.485 (1.258–1.752)

< 0.001*

1.659 (1.283–2.145)

< 0.001*

qSOFA

1.473 (0.880–2.465)

NS

  

Initial CURB-65

2.518 (1.702–3.727)

< 0.001*

2.000 (1.238–3.231)

0.005*

SOFA score

1.532 (1.284–1.827)

< 0.001*

1.730 (1.353–2.210)

< 0.001*

HO-1 catabolism

    

 Heme

0.997 (0.991–1.003)

NS

  

 HO-1

1.009 (1.004–1.014)

0.001*

1.001 (0.995–1.007)

NS

 Total bilirubin

2.254 (0.978–5.198)

NS

  

 Ferritin

1.000 (1.000–1.001)

NS

  
  1. Events: in-hospital mortality, time: days since ED admission to discharge or in-hospital mortality
  2. SOFA score was calculated within the 48 h of admission
  3. Selection: stepwise
  4. CCI Charlson comorbidity index, CI confidence interval, CURB-65 confusion; blood urea nitrogen, respiratory rate, blood pressure, in patients aged > 65 years, CtV cycle threshold value, ED emergency department, HO-1 heme oxygenase-1, HR hazard ratio, NS non-significant, qSOFA quick Sepsis-Related Organ Failure Assessment, SARS-CoV-2 severe acute respiratory syndrome-corona virus-2
  5. (*) Statistical significant (p < 0.05)
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European Journal of Medical Research

ISSN: 2047-783X

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