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Fig. 5 | European Journal of Medical Research

Fig. 5

From: A novel stop-gain pathogenic variant in FLT4 and a nonsynonymous pathogenic variant in PTPN11 associated with congenital heart defects

Fig. 5

The binding pattern of the normal/mutant src homology region 2 domain phosphatase-2 (SHP-2) with Grb2-associated binder-1 (Gab-1) is presented herein. A The image shows the 3D interaction between the normal SHP-2 (N-SH2 domain: violet, C-SH2 domain: limo green, PTP domain: teal) and Gab-1 (red). B The image demonstrates the 3D interaction between the mutant SHP-2 (N-SH2 domain: violet, C-SH2 domain: limo green, PTP domain: teal) and Gab-1 (red). These visualizations were obtained using the PyMOL software

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European Journal of Medical Research

ISSN: 2047-783X

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