Fig. 6From: A novel stop-gain pathogenic variant in FLT4 and a nonsynonymous pathogenic variant in PTPN11 associated with congenital heart defectsThe 2D image of ligand–protein interactions is illustrated herein. A The image demonstrates the interaction between the normal SHP-2 and Gab-1. B The image shows the interaction between the mutant SHP-2 and Gab-1. These images were generated by LigPlus + . (The green dashed lines represent hydrogen bonds with bond distance.)Back to article page