PD-1 and LAG-3-positive T cells are associated with clinical outcomes of relapsed/refractory multiple myeloma patients

Table 2 Spearman’s analysis between frequency of circulating T cells and inflammatory factors in RRMM and MM patients

		IL-6		IL-17		TGF-β		TNF-α		CRP
		Spearman correlation	p	Spearman correlation	p	Spearman correlation	p	Spearman correlation	p	Spearman correlation	p
CD4⁺	PD-1⁺	0.235	0.005	0.289	0.001	− 0.068	0.421	− 0.121	0.153	0.041	0.630
	LAG-3⁺	0.164	0.052	0.142	0.093	− 0.012	0.888	0.005	0.954	− 0.032	0.702
	PD-1⁺/LAG-3⁺	0.295	< 0.001	0.242	0.004	0.046	0.591	0.199	0.018	− 0.140	0.098
CD8⁺	PD-1⁺	0.221	0.008	0.129	0.128	0.004	0.966	0.044	0.603	− 0.022	0.796
	LAG-3⁺	0.170	0.044	0.002	0.983	0.095	0.264	0.047	0.577	− 0.084	0.319
	PD-1⁺/LAG-3⁺	0.463	< 0.001	0.439	< 0.001	− 0.058	0.495	0.098	0.250	− 0.147	0.081

ISSN: 2047-783X