PD-1 and LAG-3-positive T cells are associated with clinical outcomes of relapsed/refractory multiple myeloma patients

Table 3 Logistic regression for risk factors of RRMM

Variables	Wald	Odds ratio	95% CI	p
Age	0.592	1.016	0.975–1.059	0.442
Sex	0.620	1.327	0.656–2.684	0.431
BMI	0.668	1.041	0.945–1.147	0.414
ISS stage	0.332	0.880	0.569–1.360	0.565
Ig type	0.475	1.097	0.843–1.428	0.491
CD4⁺PD-1⁺	14.904	0.917	0.877–0.958	< 0.001
CD4⁺LAG-3⁺	1.400	0.954	0.883–1.031	0.237
CD4⁺PD-1⁺/LAG-3⁺	2.989	0.755	0.581–1.035	0.084
CD8⁺PD-1⁺	0.653	0.982	0.939–1.026	0.419
CD8⁺LAG-3⁺	< 0.001	1.000	0.943–1.060	0.997
CD8⁺PD-1⁺/LAG-3⁺	26.666	0.575	0.466–0.709	< 0.001
IL-6	19.145	0.919	0.885–0.954	< 0.001
IL-17	20.681	0.776	0.696–0.866	< 0.001
CRP	0.172	0.996	0.978–1.015	0.678
TNF-α	4.699	0.960	0.924–0.996	0.030
TGF-β	2.383	1.021	0.994–1.048	0.123

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