Fig. 1

Schematic diagram of the domain organization of HIFs. A Illustrated functional domain arrangements of HIFs. Domains: bHLH, basic helix-loop-helix (DNA binding and dimerization); PAS, Per/Ahr-ARNT/Sim (dimerization); PAS-A PAS-associated domain A; PAS-B PAS-associated domain B; ODDD: oxygen-dependent degradation domain; N-TAD, N-terminal transactivation domain (transcriptional transactivation); C-TAD, C-terminal transactivation domain (transcriptional transactivation); Factors: PHD1-3, HIF prolyl hydroxylase 1–3; VHL, von Hippel–Lindau tumor suppressor protein. CBP/P300: p300/CREB-binding protein. B 3D structural illustrations of HIF domain organization. Mouse HIF-1α:HIF-1β:HRE (DNA element) are shown as an example to show domain organizations. The structure is retrieved from the Protein Data Bank (ID: 4ZPR). Color schemes are the same as in panel A. Because the structure only contains partial sequences of HIF1α:HIF-1β, only bHLH and PAS domains are shown