Safety and long-term prognosis of simultaneous versus staged resection in synchronous colorectal cancer with liver metastasis: a systematic review and meta-analysis

Table 3 Pooled results of the comparison of all outcomes between the two groups

Outcomes	Number of studies	Number of patients		WMD/SMD/OR/HR	95% CI	Heterogeneity	P value
Outcomes	Number of studies	Simultaneous resection	Staged resection
Complications
Total complications	17	1342	1891	OR = 0.88	0.66–1.19	I² = 61.3%, P < 0.001	P = 0.409
Gastrointestinal complications	16	1358	1627	OR = 1.19	0.89–1.59	I² = 21.6%, P = 0.208	P = 0.241
Hepatic complications	17	1398	1806	OR = 1.04	0.83–1.31	I² = 0.0%, P = 0.529	P = 0.734
Perioperative characteristics
Perioperative mortality	10	730	1470	OR = 1.79	0.88–3.64	I² = 8.5%, P = 0.364	P = 0.108
Intraoperative blood loss	9	599	950	SMD = –0.39	–0.60 to –0.18	I² = 69.1%, P = 0.001	P < 0.001
Total hospital stay	13	648	946	WMD = –5.43	–7.29 to –3.58	I² = 76.9%, P < 0.001	P < 0.001
Long-term prognosis
5-year DFS	4	208	150	HR = 1.26	0.96–1.66	I² = 18.1%, P = 0.300	P = 0.098
5-year OS	10	1017	1337	HR = 1.13	0.95–1.34	I² = 34.6%, P = 0.131	P = 0.164

ISSN: 2047-783X