Table 4 DDR/R of prostate cancer cells after carbon ion/proton irradiation
Author, year | Treatment | Outcome | Finds |
|---|---|---|---|
Wang 2019 | Carbon ion irradiation | Cell cycle checkpoints | ↑miR‐16‐5p; G0-/G1-phase arrest |
Srivastava 2018 | Carbon ion irradiation + PNKPi | Cell cycle checkpoints Apoptosis | G2-/M-phase arrest Inducing the apoptosis through apoptotic body and nucleosomal DNA ladder formation |
Suetens 2016 | Carbon ion irradiation | DSB repair Cell cycle checkpoints | ↑γ-H2AX foci numbers and foci occupancy Permanent G2-/M-phase arrest |
Chen 2020 | Proton irradiation | DSB repair | ↑levels of γ-H2AX |
Wang 2020 | Carbon ion irradiation | DSB repair Cell cycle checkpoints Apoptosis | ↑γ-H2AX foci numbers, lasting time and size G2-/M-phase arrest The rates of apoptosis were 27.34% and 37.93% after 2 and 4 Gy carbon ion irradiation, respectively (versus 14.1% and 23.59% following 2 and 4 Gy X-ray irradiation, respectively) |