Fig. 2
From: High expression of GMNN predicts malignant progression and poor prognosis in ACC
Identification of the most significant module and validation of GMNN in the TCGA cohort. (A) The most significant module and GMNN as a hub gene were recognized in the PPI network. B GMNN was differentially expressed. (C–E) GMNN was significantly related to poor OS, DSS, and PFI in TCGA ACC sample. (F, G) Univariate Cox regression and multivariate Cox regression analyses indicated that GMNN was independently related to OS of TCGA ACC patients. (H–J) The expression level of GMNN was associated with stage, T, and M in ACC. (K, L) GMNN was closely related to OS and PFI of ACC patients treated with mitotane. OS overall survival, DSS disease-specific survival, PFI progression-free interval, ACC adrenocortical carcinoma