Variables | Study (n) | I2 (%) | χ2 | OR (95% CI) | Begg test (p_value) | Egger test (p_value) | Sensitivity analysis (range of OR) |
---|---|---|---|---|---|---|---|
Modifiable risk factors | |||||||
Occupation (ref = housewife) | |||||||
Employee | 9 | 83.8 | 0.001 | 1.37 (0.98,1.91) | 0.53 | 0.87 | 1.18–1.49 |
Education (ref = university) | |||||||
Illiterate | 7 | 87 | 0.001 | 1.00 (0.59–1.69) | 0.45 | 0.58 | 0.84–1.32 |
Lower than diploma | 7 | 67.5 | 0.005 | 1.01 (0.73–1.39) | 0.88 | 0.70 | 0.90–1.14 |
Marital status (ref = married) | |||||||
Single, divorced, widow | 14 | 74.1 | 0.001 | 1.18 (0.85–1.64) | 0.25 | 0.09 | 1.09–1.34 |
Place of residence (ref = rural) | |||||||
Urban | 4 | 81.1 | 0.001 | 1.46 (0.96–2.21) | 0.17 | 0.17 | 1.13–1.69 |
Age of marriage(ref = < 18) | |||||||
18–24 | 3 | 0 | 0.99 | 1.22 (1.02–1.47) | 0.60 | 0.57 | 1.22–1.23 |
25–29 | 3 | 0 | 0.41 | 2.00 (1.53–2.61) | 0.11 | 0.34 | 1.87–2.28 |
> 29 | 3 | 86.6 | 0.001 | 2.02 (0.68–5.98) | 0.11 | 0.26 | 1.23–3.48 |
BMI (ref = normal) | |||||||
Underweight (< 18.5) | 3 | 55 | 0.10 | 0.70 (0.34–1.45) | 0.60 | 0.26 | 0.56–1.05 |
Overweight (25–29.9) | 9 | 74.2 | 0.001 | 1.30 (1.00–1.70) | 0.02 | 0.07 | 1.11–1.39 |
Obese (≥ 30) | 9 | 85.7 | 0.001 | 2.17 (1.47–3.21) | 0.06 | 0.02 | 1.56–2.37 |
Physical activity (ref = regular, active) | |||||||
moderate, occasionally | 6 | 74 | 0.002 | 1.37 (0.82, 2.30) | 0.85 | 0.89 | 1.12–1.51 |
Never, seldom | 6 | 86 | 0.001 | 1.54 (0.93, 2.54) | 0.34 | 0.51 | 1.31–2.02 |
Smoking (ref = no) | |||||||
Yes | 9 | 18.9 | 0.27 | 1.83 (1.41–2.38) | 0.53 | 0.34 | 1.75- 1.88 |
Second-hand smoking (ref = no) | |||||||
Yes | 3 | 0 | 0.88 | 1.86(1.58–2.19) | 0.60 | 0.29 | 1.83–1.90 |
Alcohol use (ref = no) | |||||||
Yes | 2 | 37.6 | 0.20 | 0.59 (0.15–2.29) | 0.31 | – | 0.40–2.01 |
supplement intake (ref = no) | |||||||
Yes | 5 | 67.8 | 0.01 | 0.61 (0.35–1.07) | 0.05 | 0.04 | 0.46–0.73 |
Parity (ref = nulliparous) | |||||||
Yes | 5 | 33.2 | 0.20 | 0.94 (0.71, 1.24) | 0.62 | 0.94 | 0.88–1.06 |
Abortion history (ref = no) | |||||||
Yes | 5 | 66.3 | 0.01 | 1.44 (1.02–2.05) | 0.62 | 0.32 | 1.21–1.63 |
OCP use (ref = no) | |||||||
Yes | 13 | 74.1 | 0.001 | 1.35(1.11–1.63) | 0.80 | 0.70 | 1.26–1.41 |
HRT (ref = no) | |||||||
Yes | 5 | 58.7 | 0.04 | 1.03 (0.50–2.14) | 1 | 0.24 | 0.83–1.31 |
Breastfeeding history (ref = no) | |||||||
Yes | 8 | 0 | 0.51 | 0.92 (0.79–1.08) | 0.08 | 0.02 | 0.88-.0.93 |
Breastfeeding duration (ref = ≥ 24 months) | |||||||
< 24 months | 3 | 79.9 | 0.007 | 1.47 (0.74, 2.92) | 0.11 | 0.19 | 1.09–2.14 |
Non-modifiable risk factors | |||||||
Age of menarche (ref = ≥ 14) | |||||||
12–13 | 4 | 25.4 | 0.25 | 1.67 (1.31, 2.13) | 0.17 | 0.45 | 1.48–1.74 |
< 12 | 4 | 92.7 | 0.001 | 2.72 (0.93, 7.99) | 0.49 | 0.34 | 1.71–4.33 |
Age of menopause (ref = ≥ 49) | |||||||
< 49 | 3 | 86.3 | 0.001 | 2.03 (0.77–5.34) | 0.11 | 0.02 | 1.27–3.29 |
Menopause status (ref = no) | |||||||
Yes | 12 | 77.3 | 0.001 | 1.18 (0.90–1.55) | 0.10 | 0.30 | 1.10–1.30 |
Family history of breast cancer (ref = no) | |||||||
Yes | 11 | 73 | 0.001 | 2.47 (1.83–3.33) | 0.39 | 0.24 | 2.28–2.65 |
Family history of cancer (ref = no) | |||||||
Yes | 4 | 90.4 | 0.001 | 2.57 (0.84–7.85) | 1 | 0.54 | 1.45–3.58 |
History of radiation exposure (ref = no) | |||||||
Yes | 2 | 0 | 0.99 | 3.48 (2.17–5.59) | 0.31 | – | 3.46–3.49 |