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Table 4 Odds ratio, publication bias, heterogenicity, and sensitivity analysis of breast cancer risk factors

From: Breast cancer risk factors in Iranian women: a systematic review and meta-analysis of matched case–control studies

Variables

Study (n)

I2 (%)

χ2

OR (95% CI)

Begg test (p_value)

Egger test (p_value)

Sensitivity analysis (range of OR)

Modifiable risk factors

 Occupation (ref = housewife)

  Employee

9

83.8

0.001

1.37 (0.98,1.91)

0.53

0.87

1.18–1.49

 Education (ref = university)

  Illiterate

7

87

0.001

1.00 (0.59–1.69)

0.45

0.58

0.84–1.32

  Lower than diploma

7

67.5

0.005

1.01 (0.73–1.39)

0.88

0.70

0.90–1.14

 Marital status (ref = married)

  Single, divorced, widow

14

74.1

0.001

1.18 (0.85–1.64)

0.25

0.09

1.09–1.34

 Place of residence (ref = rural)

  Urban

4

81.1

0.001

1.46 (0.96–2.21)

0.17

0.17

1.13–1.69

 Age of marriage(ref =  < 18)

  18–24

3

0

0.99

1.22 (1.02–1.47)

0.60

0.57

1.22–1.23

  25–29

3

0

0.41

2.00 (1.53–2.61)

0.11

0.34

1.87–2.28

   > 29

3

86.6

0.001

2.02 (0.68–5.98)

0.11

0.26

1.23–3.48

 BMI (ref = normal)

  Underweight (< 18.5)

3

55

0.10

0.70 (0.34–1.45)

0.60

0.26

0.56–1.05

  Overweight (25–29.9)

9

74.2

0.001

1.30 (1.00–1.70)

0.02

0.07

1.11–1.39

  Obese (≥ 30)

9

85.7

0.001

2.17 (1.47–3.21)

0.06

0.02

1.56–2.37

 Physical activity (ref = regular, active)

  moderate, occasionally

6

74

0.002

1.37 (0.82, 2.30)

0.85

0.89

1.12–1.51

  Never, seldom

6

86

0.001

1.54 (0.93, 2.54)

0.34

0.51

1.31–2.02

 Smoking (ref = no)

  Yes

9

18.9

0.27

1.83 (1.41–2.38)

0.53

0.34

1.75- 1.88

 Second-hand smoking (ref = no)

  Yes

3

0

0.88

1.86(1.58–2.19)

0.60

0.29

1.83–1.90

 Alcohol use (ref = no)

  Yes

2

37.6

0.20

0.59 (0.15–2.29)

0.31

0.40–2.01

 supplement intake (ref = no)

  Yes

5

67.8

0.01

0.61 (0.35–1.07)

0.05

0.04

0.46–0.73

 Parity (ref = nulliparous)

  Yes

5

33.2

0.20

0.94 (0.71, 1.24)

0.62

0.94

0.88–1.06

 Abortion history (ref = no)

  Yes

5

66.3

0.01

1.44 (1.02–2.05)

0.62

0.32

1.21–1.63

 OCP use (ref = no)

  Yes

13

74.1

0.001

1.35(1.11–1.63)

0.80

0.70

1.26–1.41

 HRT (ref = no)

  Yes

5

58.7

0.04

1.03 (0.50–2.14)

1

0.24

0.83–1.31

 Breastfeeding history (ref = no)

  Yes

8

0

0.51

0.92 (0.79–1.08)

0.08

0.02

0.88-.0.93

 Breastfeeding duration (ref =  ≥ 24 months)

   < 24 months

3

79.9

0.007

1.47 (0.74, 2.92)

0.11

0.19

1.09–2.14

 Non-modifiable risk factors

  Age of menarche (ref =  ≥ 14)

  12–13

4

25.4

0.25

1.67 (1.31, 2.13)

0.17

0.45

1.48–1.74

   < 12

4

92.7

0.001

2.72 (0.93, 7.99)

0.49

0.34

1.71–4.33

 Age of menopause (ref =  ≥ 49)

     < 49

3

86.3

0.001

2.03 (0.77–5.34)

0.11

0.02

1.27–3.29

 Menopause status (ref = no)

  Yes

12

77.3

0.001

1.18 (0.90–1.55)

0.10

0.30

1.10–1.30

 Family history of breast cancer (ref = no)

  Yes

11

73

0.001

2.47 (1.83–3.33)

0.39

0.24

2.28–2.65

 Family history of cancer (ref = no)

  Yes

4

90.4

0.001

2.57 (0.84–7.85)

1

0.54

1.45–3.58

 History of radiation exposure (ref = no)

  Yes

2

0

0.99

3.48 (2.17–5.59)

0.31

3.46–3.49

  1. Statistical significant OR with P-value less than 0.05 are highlighted in bold