A model for predicting overall survival in bladder cancer patients with signet ring cell carcinoma: a population-based study

Liu, Liang; Li, Chuangui; Wang, Qiang; Yuan, Haibo; Wang, Yuanyuan

doi:10.1186/s40001-022-00970-y

Table 2 Univariate and multivariable analyses of prognostic factors for primary bladder SRCC

From: A model for predicting overall survival in bladder cancer patients with signet ring cell carcinoma: a population-based study

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	P value	HR	95% CI	P value
Sex
Female	Reference			Reference
Male	0.536	0.348 ~ 0.825	0.005^a	0.586	0.329 ~ 1.041	0.068
Age, year
< 60	Reference
≥ 60	1.138	0.749 ~ 1.728	0.545
Race
White	Reference			Reference
Black	1.292	0.717 ~ 2.327	0.394	1.775	0.839 ~ 3.753	0.133
Others	2.157	0.781 ~ 5.956	0.138	2.265	0.558 ~ 9.183	0.252
Unknown	66.305	6.556 ~ 670.578	< 0.001^b	59.085	2.638 ~ 913.422	0.009^a
Marital status
Single	Reference			Reference
Married	0.837	0.472 ~ 1.478	0.540	1.264	0.629 ~ 2.540	0.511
SDW	3.416	1.709 ~ 6.830	< 0.001^b	2.878	1.296 ~ 6.391	0.009^a
Others	0.632	0.209 ~ 1.909	0.415	1.758	0.485 ~ 6.372	0.390
Primary site
Trigone of bladder	Reference
Dome of bladder	0.890	0.317 ~ 2.494	0.825
Lateral wall of bladder	1.346	0.520 ~ 3.487	0.540
Anterior wall of bladder	1.487	0.308 ~ 7.175	0.621
Posterior wall of bladder	1.127	0.377 ~ 3.367	0.830
Bladder neck	1.252	0.322 ~ 4.853	0.745
Ureteric orifice	0.386	0.046 ~ 3.207	0.378
Urachus	0.646	0.188 ~ 2.217	0.487
Overlapping lesion of bladder	1.464	0.603 ~ 3.556	0.400
Bladder, NOS	1.443	0.643 ~ 3.239	0.374
Tumor size, cm
< 4.0	Reference			Reference
≥ 4.0	2.437	1.326 ~ 4.478	0.004^a	1.969	0.978 ~ 3.962	0.058
Unknown	2.058	1.215 ~ 3.486	0.007^a	1.937	0.997 ~ 3.764	0.051
Grade
II	Reference
III	3.246	0.446 ~ 23.650	0.245
IV	2.734	0.372 ~ 20.090	0.323
Unknown	2.083	0.278 ~ 15.610	0.475
T stage
T1	Reference			Reference
T2	1.555	0.782 ~ 3.093	0.208	2.710	1.127 ~ 6.518	0.026^a
T3	2.486	1.186 ~ 5.212	0.015^a	6.124	1.881 ~ 19.924	0.003^a
T4	2.569	1.307 ~ 5.049	0.006^a	4.141	1.534 ~ 11.252	0.005^a
TX	3.263	1.209 ~ 8.805	0.020^a	1.455	0.394 ~ 5.365	0.574
N stage
N0	Reference			Reference
N1	1.688	0.915 ~ 3.115	0.094	2.242	0.900 ~ 5.604	0.085
N2	2.247	1.309 ~ 3.859	0.003^a	4.461	2.016 ~ 9.873	< 0.001^b
N3	2.116	0.289 ~ 15.484	0.461	6.957	0.739 ~ 65.460	0.090
NX	2.214	0.780 ~ 6.139	0.127	0.954	0.190 ~ 4.790	0.954
M stage
M0	Reference			Reference
M1	3.898	2.355 ~ 6.452	< 0.001^b	2.400	1.156 ~ 4.983	0.019^a
MX	1.317	0.528 ~ 3.287	0.554	0.982	0.235 ~ 4.095	0.980
Surgery
None	Reference			Reference
TURB	0.498	0.256 ~ 0.972	0.040^a	0.539	0.203 ~ 1.431	0.215
Complete cystectomy + reconstruction	0.275	0.131 ~ 0.579	< 0.001^b	0.362	0.116 ~ 1.131	0.080
Pelvic exenteration	0.371	0.178 ~ 0.777	0.008^a	0.223	0.069 ~ 0.726	0.012^a
Others	0.349	0.160 ~ 0.762	0.008^a	0.194	0.064 ~ 0.591	0.004^a
Lymph nodes removed
None	Reference			Reference
1 to 3 regional	0.522	0.207 ~ 1.315	0.168	0.367	0.090 ~ 1.498	0.163
4 or more regional	0.540	0.345 ~ 0.867	0.007^a	0.299	0.127 ~ 0.703	0.006^a
Unknown	0.852	0.309 ~ 2.350	0.756	0.120	0.023 ~ 0.627	0.012^a
Surgery/Radiation sequence
No radiation and/or surgery	Reference
Radiation after surgery	1.773	0.958 ~ 3.283	0.068
Radiation before and after surgery	1.046	1.145 ~ 7.554	0.965
Radiation
None/Unknown	Reference			Reference
Yes	1.773	1.024 ~ 3.070	0.041^a	0.552	0.227 ~ 1.343	0.190
Chemotherapy
None/Unknown	Reference
Yes	1.078	0.713 ~ 1.630	0.722

SDW Divorced + Separated + Widowed + Unmarried or Domestic Partner, TURB transurethral resection of the bladder
^aP < 0.05
^bP < 0.001

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