Skip to main content

Table 1 Baseline characteristics, vital signs, laboratory results of patients with CKD and CAD from MIMIC-IV database

From: The prediction of in-hospital mortality in chronic kidney disease patients with coronary artery disease using machine learning models

 

Overall

Survivor

P-Value

 

3590

3054

 

Age (years)

76.0 [68.0, 84.0]

75.0 [68.0, 83.0]

< 0.001

Male, n (%)

2451 (68.3)

2100 (68.8)

0.146

los_icu (day)

2.2 [1.2, 4.1]

2.2 [1.2, 4.0]

0.01

scr_baseline (mg/dL)

1.4 [1.1, 2.0]

1.4 [1.1, 1.9]

 < 0.001

eGFR (mL/min/1.73 m2)

47.2 (24.2)

48.4 (23.8)

 < 0.001

CKD stage, n (%)

   

 1

166 (4.6)

142 (4.6)

 < 0.001

 2

871 (24.3)

792 (25.9)

 

 3

1581 (44.0)

1373 (45.0)

 

 4

655 (18.2)

506 (16.6)

 

 5

137 (3.8)

92 (3.0)

 

 Dialysis

180 (5.0)

149 (4.9)

 

ACS, n (%)

1049 (29.2)

886 (29.0)

0.545

Myocardial infarct, n (%)

2423 (67.5)

2014 (65.9)

 < 0.001

Congestive heart failure, n (%)

2313 (64.4)

1925 (63.0)

 < 0.001

Peripheral vascular disease, n (%)

847 (23.6)

713 (23.3)

0.437

Cerebrovascular disease, n (%)

573 (16.0)

468 (15.3)

0.015

Dementia, n (%)

189 (5.3)

150 (4.9)

0.031

Chronic pulmonary disease, n (%)

1067 (29.7)

890 (29.1)

0.078

Rheumatic disease, n (%)

138 (3.8)

119 (3.9)

0.788

Peptic ulcer disease, n (%)

111 (3.1)

92 (3.0)

0.602

Diabetes with control, n (%)

1359 (37.9)

1181 (38.7)

0.018

Diabetes without_control, n (%)

1065 (29.7)

887 (29.0)

0.058

Malignant cancer, n (%)

338 (9.4)

265 (8.7)

 < 0.001

Mild liver disease, n (%)

262 (7.3)

189 (6.2)

 < 0.001

Severe liver disease, n (%)

74 (2.1)

46 (1.5)

 < 0.001

HT, n (%)

3300 (91.9)

2811 (92.0)

0.582

Atrial fibrillation or flutter, n (%)

1638 (45.6)

1339 (43.8)

 < 0.001

Ventricular arrhythmia, n (%)

195 (5.4)

129 (4.2)

 < 0.001

Cardiac arrest, n (%)

160 (4.5)

79 (2.6)

 < 0.001

PCI, n (%)

195 (5.4)

175 (5.7)

0.075

CABG, n (%)

624 (17.4)

610 (20.0)

 < 0.001

Aspirin, n (%)

3009 (83.8)

2622 (85.9)

 < 0.001

Clopidogrel, n (%)

1114 (31.0)

975 (31.9)

0.007

Ticagrelor, n (%)

2 (0.1)

1 (0.0)

0.276

Statin, n (%)

3005 (83.7)

2647 (86.7)

 < 0.001

Beta_blocker, n (%)

2618 (72.9)

2334 (76.4)

 < 0.001

NOAC, n (%)

262 (7.3)

243 (8.0)

 < 0.001

Warfarin, n (%)

908 (25.3)

835 (27.3)

 < 0.001

Inhospital hemodialysis, n (%)

250 (7.0)

193 (6.3)

 < 0.001

Inhospital peritoneal_dialysis, n (%)

8 (0.2)

8 (0.3)

0.615

Inhospital CRRT, n (%)

587 (16.4)

449 (14.7)

 < 0.001

Troponin_max (ng/mL)

0.2 [0.1, 1.2]

0.2 [0.1, 0.9]

 < 0.001

Troponin_min (ng/mL)

0.1 [0.1, 0.5]

0.1 [0.0, 0.4]

 < 0.001

Troponin_mean (ng/mL)

0.2 [0.1, 0.8]

0.2 [0.1, 0.7]

 < 0.001

WBC_max (K/µL)

14.1 [10.5, 19.3]

13.6 [10.1, 18.4]

 < 0.001

WBC_min (K/Ul)

6.8 [5.3, 8.6]

6.7 [5.2, 8.3]

 < 0.001

WBC_mean (K/Ul)

10.0 [7.8, 12.7]

9.6 [7.6, 12.1]

 < 0.001

RBC_max (m/µL)

3.7 [3.3, 4.2]

3.7 [3.3, 4.2]

0.029

RBC_min (m/Ul)

2.8 [2.4, 3.3]

2.8 [2.4, 3.2]

0.144

RBC_mean (m/Ul)

3.2 [2.9, 3.6]

3.2 [2.9, 3.6]

0.176

Hemoglobin_max (g/dL)

11.1 [9.9, 12.4]

11.1 [10.0, 12.4]

0.012

Hemoglobin_min (g/dL)

8.2 [7.2, 9.6]

8.2 [7.2, 9.6]

0.034

Hemoglobin_mean (g/dL)

9.6 [8.6, 10.7]

9.6 [8.7, 10.7]

0.049

Hematocrit_max (%)

34.1 [31.0, 38.1]

34.1 [31.0, 38.1]

0.473

Hematocrit_min (%)

25.3 [22.3, 29.7]

25.2 [22.3, 29.6]

0.949

Hematocrit_mean (%)

29.4 [26.9, 32.8]

29.4 [26.9, 32.7]

0.838

Platelet_max (K/µL)

247.0 [186.0, 325.0]

250.5 [191.0, 329.0]

 < 0.001

Platelet_min (K/µL

136.0 [100.0, 185.0]

138.0 [102.0, 187.0]

 < 0.001

Platelet_mean (K/µL)

186.2 [144.1, 239.8]

189.3 [148.0, 241.4]

 < 0.001

ALT_max (IU/L)

27.0 [16.0, 62.0]

25.0 [16.0, 49.0]

 < 0.001

ALT_min (IU/L)

18.0 [12.0, 31.0]

18.0 [12.0, 29.0]

 < 0.001

ALT_mean (IU/L)

23.2 [15.0, 45.5]

21.8 [14.0, 39.0]

 < 0.001

AST_max (IU/L)

42.0 [24.0, 104.0]

38.0 [23.0, 82.0]

 < 0.001

AST_min (IU/L)

25.0 [18.0, 38.0]

24.0 [17.0, 35.0]

 < 0.001

AST_mean (IU/L)

33.3 [22.0, 63.0]

31.0 [21.0, 52.2]

 < 0.001

ALP_max (IU/L)

93.0 [70.0, 134.0]

90.0 [68.0, 125.8]

 < 0.001

ALP_min (IU/L)

77.0 [59.0, 102.0]

76.0 [58.0, 100.0]

 < 0.001

ALP_mean (IU/L)

86.0 [67.0, 115.5]

84.0 [66.0, 111.0]

 < 0.001

Bilirubin_total_max (mg/dL)

0.6 [0.4, 1.0]

0.6 [0.4, 0.9]

 < 0.001

Bilirubin_total_min (mg/dL)

0.4 [0.3, 0.7]

0.4 [0.3, 0.7]

 < 0.001

Bilirubin_total_mean (mg/dL)

0.5 [0.4, 0.8]

0.5 [0.3, 0.8]

 < 0.001

Creatinine_max (mg/dL)

2.4 [1.6, 4.0]

2.2 [1.6, 3.7]

 < 0.001

Creatinine_min (mg/dL)

1.4 [1.1, 2.0]

1.4 [1.1, 1.9]

 < 0.001

Creatinine_mean (mg/dL)

1.8 [1.4, 2.9]

1.8 [1.3, 2.7]

 < 0.001

BUN_max (mg/dL)

52.0 [36.0, 77.0]

50.0 [34.0, 73.0]

 < 0.001

BUN_min (mg/dL)

24.0 [17.0, 36.0]

23.0 [17.0, 34.0]

 < 0.001

BUN_mean (mg/dL)

38.4 [27.0, 54.0]

36.3 [26.1, 50.9]

 < 0.001

Potassium_max (mEq/L)

5.0 [4.6, 5.6]

5.0 [4.6, 5.5]

 < 0.001

Potassium_min (mEq/L)

3.6 [3.3, 4.0]

3.6 [3.4, 3.9]

0.278

Potassium_mean (mEq/L)

4.3 [4.0, 4.6]

4.3 [4.0, 4.5]

 < 0.001

Sodium_max (mEq/L)

142.0 [140.0, 145.0]

142.0 [140.0, 145.0]

0.049

Sodium_min (mEq/L)

134.0 [131.0, 137.0]

135.0 [131.0, 137.0]

0.005

Sodium_mean (mEq/L)

138.3 [136.0, 140.7]

138.3 [136.2, 140.6]

0.386

Total_calcium_max (mg/dL)

9.1 [8.7, 9.6]

9.1 [8.7, 9.5]

0.533

Total_calcium_min (mg/dL)

8.0 [7.6, 8.4]

8.1 [7.7, 8.5]

 < 0.001

Total_calcium_mean (mg/dL)

8.6 [8.2, 8.9]

8.6 [8.2, 8.9]

 < 0.001

Free_calcium_max (mmol/L)

1.2 [1.1, 1.2]

1.2 [1.1, 1.2]

 < 0.001

Free_calcium_min (mmol/L)

1.1 [1.0, 1.1]

1.1 [1.0, 1.1]

 < 0.001

Free_calcium_mean (mmol/L)

1.1 [1.1, 1.2]

1.1 [1.1, 1.2]

 < 0.001

Magnesium_max (mg/dL)

2.5 [2.3, 2.8]

2.5 [2.3, 2.8]

0.234

Magnesium_min (mg/dL)

1.8 [1.7, 2.0]

1.8 [1.7, 2.0]

0.559

Magnesium_mean (mg/dL)

2.1 [2.0, 2.3]

2.1 [2.0, 2.3]

0.002

Phosphate_max (mg/dL)

4.9 [4.0, 6.2]

4.7 [4.0, 5.8]

 < 0.001

Phosphate_min (mg/dL)

2.8 [2.2, 3.4]

2.8 [2.3, 3.3]

 < 0.001

Phosphate_mean (mg/dL)

3.8 [3.2, 4.5]

3.7 [3.2, 4.3]

 < 0.001

INR_max

1.5 [1.2, 2.3]

1.4 [1.2, 2.0]

 < 0.001

INR_min

1.1 [1.0, 1.2]

1.1 [1.0, 1.2]

 < 0.001

INR_mean

1.3 [1.1, 1.6]

1.2 [1.1, 1.5]

 < 0.001

PT_max (s)

16.1 [13.6, 24.3]

15.7 [13.4, 22.3]

 < 0.001

PT_min (s)

12.4 [11.4, 13.8]

12.2 [11.4, 13.4]

 < 0.001

PT_mean (s)

14.1 [12.6, 17.2]

13.8 [12.5, 16.1]

 < 0.001

PTT_max (s)

45.4 [31.9, 105.2]

42.5 [31.4, 97.8]

 < 0.001

PTT_min (s)

27.6 [25.3, 30.7]

27.4 [25.2, 30.2]

 < 0.001

PTT_mean (s)

35.9 [29.4, 54.2]

34.7 [29.1, 52.0]

 < 0.001

Glucose_max (mg/dL)

194.0 [149.0, 271.0]

189.0 [147.0, 261.0]

 < 0.001

Glucose_min (mg/dL)

88.0 [74.0, 103.0]

87.0 [74.0, 101.0]

 < 0.001

Glucose_mean (mg/dL)

131.2 [111.8, 162.7]

128.2 [110.6, 157.7]

 < 0.001

SOFA

6.0 [4.0, 8.0]

5.0 [3.0, 7.0]

 < 0.001

BMI (kg/m2)

28.0 [24.2, 32.6]

28.1 [24.3, 32.6]

0.018

sbp_max (mmHg)

155.0 [140.0, 172.0]

156.0 [141.0, 173.0]

 < 0.001

sbp_min (mmHg)

85.0 [75.0, 96.0]

87.0 [78.0, 97.0]

 < 0.001

sbp_mean (mmHg)

117.7 [107.9, 129.5]

119.1 [109.9, 130.6]

 < 0.001

dbp_max (mmHg)

93.0 [80.0, 109.0]

93.0 [80.0, 109.0]

0.08

dbp_min (mmHg)

39.0 [33.0, 46.0]

40.0 [34.0, 47.0]

 < 0.001

dbp_mean (mmHg)

58.7 [52.8, 65.2]

59.0 [53.2, 65.7]

 < 0.001

mbp_max (mmHg)

108.0 [96.0, 125.0]

108.0 [96.0, 124.0]

0.52

mbp_min (mmHg)

53.0 [46.0, 60.0]

54.0 [47.0, 61.0]

 < 0.001

bmp_mean (mmHg)

74.9 [69.4, 81.4]

75.6 [70.1, 82.0]

 < 0.001

HR_max (beats/min)

102.0 [88.0, 120.0]

100.0 [88.0, 116.0]

 < 0.001

HR_min (beats/min)

62.0 [55.0, 70.0]

62.0 [56.0, 70.0]

 < 0.001

HR_mean (beats/min)

79.8 [71.4, 88.9]

79.0 [71.0, 87.4]

 < 0.001

spo2_max

100[100.0, 100.0]

100[100.0, 100.0]

0.004

spo2_min

90.0 [86.0, 93.0]

91.0 [88.0, 93.0]

 < 0.001

spo2_mean

96.7 [95.6, 97.8]

96.7 [95.6, 97.8]

0.005

  1. los_icu length of stay in intensive care unit, scr serum creatinine, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, ACS acute coronary syndrome, HT hypertension, PCI percutaneous coronary intervention, CABG coronary artery bypass grafting, NOAC non-vitamin K Antagonist Oral Anticoagulant, CRRT continuous renal replacement therapy, max maximum, min minimum, WBC white blood cell, RBC red blood cell, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, BUN blood urea nitrogen, INR International Normalized Ratio, PT prothrombin time, PTT partial thromboplastin time, SOFA sequential organ failure assessment, sbp systolic blood pressure, dbp diastolic blood pressure, mbp mean blood pressure, HR heart rate, spo2 oxyhemoglobin saturation
Back to article page

European Journal of Medical Research

ISSN: 2047-783X

Contact us